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VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.
Sharma D, Lau E, Qin Y, Jee K, Rodrigues M, Guo C, Dinabandhu A, McIntyre E, Salman S, Hwang Y, Moshiri A, Semenza GL, Montaner S, Sodhi A. Sharma D, et al. Among authors: semenza gl. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2322759121. doi: 10.1073/pnas.2322759121. Epub 2024 Nov 5. Proc Natl Acad Sci U S A. 2024. PMID: 39499641
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, Wicks EE, Huang TY, Drehmer D, Wang Y, Zuo Q, Datan E, Jackson W 3rd, Dordai D, Wang R, Semenza GL. Lyu Y, et al. Among authors: semenza gl. Cell Rep. 2024 Apr 23;43(4):113972. doi: 10.1016/j.celrep.2024.113972. Epub 2024 Mar 21. Cell Rep. 2024. PMID: 38517892 Free article.
451 results