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Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Cutler M, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Drigo RAE. Dos Santos C, et al. Among authors: cartailler jp. Res Sq [Preprint]. 2023 Sep 20:rs.3.rs-3311459. doi: 10.21203/rs.3.rs-3311459/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2. PMID: 37790446 Free PMC article. Updated. Preprint.
Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia.
McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP. McKenna NJ, et al. Among authors: cartailler jp. Mol Endocrinol. 2012 Oct;26(10):1675-81. doi: 10.1210/me.2012-1077. Epub 2012 Jun 25. Mol Endocrinol. 2012. PMID: 22734043 Free PMC article.
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis.
Romero-Morales AI, Robertson GL, Rastogi A, Rasmussen ML, Temuri H, McElroy GS, Chakrabarty RP, Hsu L, Almonacid PM, Millis BA, Chandel NS, Cartailler JP, Gama V. Romero-Morales AI, et al. Among authors: cartailler jp. Development. 2022 Oct 15;149(20):dev199914. doi: 10.1242/dev.199914. Epub 2022 Jul 6. Development. 2022. PMID: 35792828 Free PMC article.
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SC, MacDonald PE, Levy SE, Powers AC, Brissova M. Shrestha S, et al. Among authors: cartailler jp. JCI Insight. 2021 Sep 22;6(18):e151621. doi: 10.1172/jci.insight.151621. JCI Insight. 2021. PMID: 34428183 Free PMC article.
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R. Shrestha S, et al. Among authors: cartailler jp. Sci Adv. 2022 Oct 7;8(40):eabo3932. doi: 10.1126/sciadv.abo3932. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197983 Free PMC article.
42 results