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Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor.
Ivanisevic T, Steklov M, Lechat B, Cawthorne C, Gsell W, Velde GV, Deroose C, Van Laere K, Himmelreich U, Sewduth RN, Sablina AA. Ivanisevic T, et al. Among authors: steklov m. Cancer Commun (Lond). 2023 Dec;43(12):1386-1390. doi: 10.1002/cac2.12490. Epub 2023 Oct 27. Cancer Commun (Lond). 2023. PMID: 37890861 Free PMC article. No abstract available.
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.
Steklov M, Pandolfi S, Baietti MF, Batiuk A, Carai P, Najm P, Zhang M, Jang H, Renzi F, Cai Y, Abbasi Asbagh L, Pastor T, De Troyer M, Simicek M, Radaelli E, Brems H, Legius E, Tavernier J, Gevaert K, Impens F, Messiaen L, Nussinov R, Heymans S, Eyckerman S, Sablina AA. Steklov M, et al. Science. 2018 Dec 7;362(6419):1177-1182. doi: 10.1126/science.aap7607. Epub 2018 Nov 15. Science. 2018. PMID: 30442762 Free PMC article.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Baietti MF, Simicek M, Abbasi Asbagh L, Radaelli E, Lievens S, Crowther J, Steklov M, Aushev VN, Martínez García D, Tavernier J, Sablina AA. Baietti MF, et al. Among authors: steklov m. EMBO Mol Med. 2016 Mar 1;8(3):288-303. doi: 10.15252/emmm.201505972. EMBO Mol Med. 2016. PMID: 26881969 Free PMC article.
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