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Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity.
Miksza DR, Biazi GR, Frasson IG, de Souza Galia WB, Ferraz LS, Diaz BF, Kurauti MA, Marmentini C, Mareze-Costa CE, Peres SB, Cassolla P, Bertolini GL, Bazotte RB, de Souza HM. Miksza DR, et al. Pharmacol Rep. 2023 Dec;75(6):1571-1587. doi: 10.1007/s43440-023-00533-w. Epub 2023 Oct 7. Pharmacol Rep. 2023. PMID: 37804392
Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide.
Quintilhano DL, Miksza DR, de Souza Galia WB, Ramalho MORC, Lucena CF, Valle MMR, Graciano MFR, de Souza HM, Bertolini GL. Quintilhano DL, et al. Among authors: miksza dr. Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr;394(4):697-705. doi: 10.1007/s00210-020-02006-w. Epub 2020 Oct 31. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 33128591
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