Grädler U - Search Results

1

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.

Grädler U, Schwarz D, Wegener A, Eichhorn T, Bandeiras TM, Freitas MC, Lammens A, Ganichkin O, Augustin M, Minguzzi S, Becker F, Bomke J. Grädler U, et al. J Biol Chem. 2023 Nov;299(11):105328. doi: 10.1016/j.jbc.2023.105328. Epub 2023 Oct 6. J Biol Chem. 2023. PMID: 37806493 Free PMC article.

2

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.

Grädler U, Gerber HD, Goodenough-Lashua DM, Garcia GA, Ficner R, Reuter K, Stubbs MT, Klebe G. Grädler U, et al. J Mol Biol. 2001 Feb 23;306(3):455-67. doi: 10.1006/jmbi.2000.4256. J Mol Biol. 2001. PMID: 11178905

3

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Buchstaller HP, Eggenweiler HM, Sirrenberg C, Grädler U, Musil D, Hoppe E, Zimmermann A, Schwartz H, März J, Bomke J, Wegener A, Wolf M. Buchstaller HP, et al. Among authors: gradler u. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4396-403. doi: 10.1016/j.bmcl.2012.04.121. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632933

4

Structural and biophysical characterization of the Syk activation switch.

Grädler U, Schwarz D, Dresing V, Musil D, Bomke J, Frech M, Greiner H, Jäkel S, Rysiok T, Müller-Pompalla D, Wegener A. Grädler U, et al. J Mol Biol. 2013 Jan 23;425(2):309-33. doi: 10.1016/j.jmb.2012.11.007. Epub 2012 Nov 12. J Mol Biol. 2013. PMID: 23154170

5

Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.

Heinrich T, Seenisamy J, Emmanuvel L, Kulkarni SS, Bomke J, Rohdich F, Greiner H, Esdar C, Krier M, Grädler U, Musil D. Heinrich T, et al. Among authors: gradler u. J Med Chem. 2013 Feb 14;56(3):1160-70. doi: 10.1021/jm3016014. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294348

6

Fragment-based discovery of focal adhesion kinase inhibitors.

Grädler U, Bomke J, Musil D, Dresing V, Lehmann M, Hölzemann G, Greiner H, Esdar C, Krier M, Heinrich T. Grädler U, et al. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5401-9. doi: 10.1016/j.bmcl.2013.07.050. Epub 2013 Jul 31. Bioorg Med Chem Lett. 2013. PMID: 23973211

7

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.

Grädler U, Schwarz D, Blaesse M, Leuthner B, Johnson TL, Bernard F, Jiang X, Marx A, Gilardone M, Lemoine H, Roche D, Jorand-Lebrun C. Grädler U, et al. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126717. doi: 10.1016/j.bmcl.2019.126717. Epub 2019 Oct 16. Bioorg Med Chem Lett. 2019. PMID: 31635932 Free PMC article.

8

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.

Paiva ACF, Lemos AR, Busse P, Martins MT, Silva DO, Freitas MC, Santos SP, Freire F, Barrey EJ, Manival X, Koetzner L, Heinrich T, Wegener A, Grädler U, Bandeiras TM, Schwarz D, Sousa PMF. Paiva ACF, et al. Among authors: gradler u. Biosensors (Basel). 2023 Oct 5;13(10):913. doi: 10.3390/bios13100913. Biosensors (Basel). 2023. PMID: 37887106 Free PMC article.

9

Cryo-EM Structures of CRAF₂/14-3-3₂ and CRAF₂/14-3-3₂/MEK1₂ Complexes.

Dedden D, Nitsche J, Schneider EV, Thomsen M, Schwarz D, Leuthner B, Grädler U. Dedden D, et al. Among authors: gradler u. J Mol Biol. 2024 Mar 15;436(6):168483. doi: 10.1016/j.jmb.2024.168483. Epub 2024 Feb 7. J Mol Biol. 2024. PMID: 38331211

10

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz DA, Richter L, Amaral M, Grandits M, Grädler U, Musil D, Buchstaller HP, Eggenweiler HM, Frech M, Ecker GF. Schuetz DA, et al. Among authors: gradler u. J Med Chem. 2018 May 24;61(10):4397-4411. doi: 10.1021/acs.jmedchem.8b00080. Epub 2018 May 10. J Med Chem. 2018. PMID: 29701469

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