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Page 1
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ; UCSF COMET Consortium; Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. Hackney JA, et al. Among authors: sarma a. iScience. 2023 Sep 1;26(10):107813. doi: 10.1016/j.isci.2023.107813. eCollection 2023 Oct 20. iScience. 2023. PMID: 37810211 Free PMC article.
Biomarkers and Precision Medicine: State of the Art.
Sarma A, Calfee CS, Ware LB. Sarma A, et al. Crit Care Clin. 2020 Jan;36(1):155-165. doi: 10.1016/j.ccc.2019.08.012. Epub 2019 Oct 22. Crit Care Clin. 2020. PMID: 31733677 Review.
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA; COMET Consortium; Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Sarma A, et al. Res Sq [Preprint]. 2021 Jan 14:rs.3.rs-141578. doi: 10.21203/rs.3.rs-141578/v1. Res Sq. 2021. Update in: Nat Commun. 2021 Aug 26;12(1):5152. doi: 10.1038/s41467-021-25040-5 PMID: 33469573 Free PMC article. Updated. Preprint.
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL; COMET Consortium; Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. Tsitsiklis A, et al. Among authors: sarma a. medRxiv [Preprint]. 2021 Nov 30:2021.03.23.21253487. doi: 10.1101/2021.03.23.21253487. medRxiv. 2021. PMID: 33791731 Free PMC article. Preprint.
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL; COMET Consortium; Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. Tsitsiklis A, et al. Among authors: sarma a. Res Sq [Preprint]. 2021 Apr 23:rs.3.rs-380803. doi: 10.21203/rs.3.rs-380803/v1. Res Sq. 2021. PMID: 34013247 Free PMC article. Preprint.
The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.
Ditz B, Sarma A, Kerstjens HAM, Liesker JJW, Bathoorn E, Vonk JM, Bernal V, Horvatovich P, Guryev V, Caldera S, Langelier C, Faiz A, Christenson SA, van den Berge M. Ditz B, et al. Among authors: sarma a. ERJ Open Res. 2021 Jul 5;7(3):00097-2021. doi: 10.1183/23120541.00097-2021. eCollection 2021 Jul. ERJ Open Res. 2021. PMID: 34235210 Free PMC article.
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS. Sinha P, et al. Among authors: sarma a. Thorax. 2022 Jan;77(1):13-21. doi: 10.1136/thoraxjnl-2021-217158. Epub 2021 Jul 12. Thorax. 2022. PMID: 34253679 Free PMC article.
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA; COMET Consortium; Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Sarma A, et al. Nat Commun. 2021 Aug 26;12(1):5152. doi: 10.1038/s41467-021-25040-5. Nat Commun. 2021. PMID: 34446707 Free PMC article.
Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. Wick KD, et al. Among authors: sarma a. Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L152-L164. doi: 10.1152/ajplung.00503.2021. Epub 2022 Jun 7. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35670478 Free PMC article.
560 results