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The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, Ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. Weisshaar N, et al. Among authors: kunze rohrbach n. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9. Nat Immunol. 2023. PMID: 37813964 Free PMC article.
Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis.
Gegner HM, Naake T, Dugourd A, Müller T, Czernilofsky F, Kliewer G, Jäger E, Helm B, Kunze-Rohrbach N, Klingmüller U, Hopf C, Müller-Tidow C, Dietrich S, Saez-Rodriguez J, Huber W, Hell R, Poschet G, Krijgsveld J. Gegner HM, et al. Among authors: kunze rohrbach n. Front Mol Biosci. 2022 Dec 20;9:961448. doi: 10.3389/fmolb.2022.961448. eCollection 2022. Front Mol Biosci. 2022. PMID: 36605986 Free PMC article.
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens.
Gegner HM, Naake T, Aljakouch K, Dugourd A, Kliewer G, Müller T, Schilling D, Schneider MA, Kunze-Rohrbach N, Grünewald TGP, Hell R, Saez-Rodriguez J, Huber W, Poschet G, Krijgsveld J. Gegner HM, et al. Among authors: kunze rohrbach n. Clin Proteomics. 2024 Jul 5;21(1):49. doi: 10.1186/s12014-024-09501-9. Clin Proteomics. 2024. PMID: 38969985 Free PMC article.