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Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor.
Papadopoulos KP, Isaacs R, Bilic S, Kentsch K, Huet HA, Hofmann M, Rasco D, Kundamal N, Tang Z, Cooksey J, Mahipal A. Papadopoulos KP, et al. Among authors: mahipal a. Cancer Chemother Pharmacol. 2015 May;75(5):887-95. doi: 10.1007/s00280-015-2712-0. Epub 2015 Feb 27. Cancer Chemother Pharmacol. 2015. PMID: 25721064 Clinical Trial.
Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF-Mutant Melanoma.
Delord JP, Robert C, Nyakas M, McArthur GA, Kudchakar R, Mahipal A, Yamada Y, Sullivan R, Arance A, Kefford RF, Carlino MS, Hidalgo M, Gomez-Roca C, Michel D, Seroutou A, Aslanis V, Caponigro G, Stuart DD, Moutouh-de Parseval L, Demuth T, Dummer R. Delord JP, et al. Among authors: mahipal a. Clin Cancer Res. 2017 Sep 15;23(18):5339-5348. doi: 10.1158/1078-0432.CCR-16-2923. Epub 2017 Jun 13. Clin Cancer Res. 2017. PMID: 28611198 Free article. Clinical Trial.
172 results