Backos DS - Search Results

1

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors.

Gates CA, Backos DS, Reigan P, Natale NR. Gates CA, et al. Among authors: backos ds. Molecules. 2023 Sep 25;28(19):6800. doi: 10.3390/molecules28196800. Molecules. 2023. PMID: 37836643 Free PMC article.

2

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.

Gates C, Backos DS, Reigan P, Kang HJ, Koerner C, Mirzaei J, Natale NR. Gates C, et al. Among authors: backos ds. Bioorg Med Chem. 2018 Sep 15;26(17):4797-4803. doi: 10.1016/j.bmc.2018.08.012. Epub 2018 Aug 10. Bioorg Med Chem. 2018. PMID: 30143366 Free PMC article.

3

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.

Steiger SA, Li C, Backos DS, Reigan P, Natale NR. Steiger SA, et al. Among authors: backos ds. Bioorg Med Chem. 2017 Jun 15;25(12):3223-3234. doi: 10.1016/j.bmc.2017.04.008. Epub 2017 Apr 8. Bioorg Med Chem. 2017. PMID: 28434782 Free PMC article.

4

AIMing towards improved antitumor efficacy.

Weaver MJ, Kearns AK, Stump S, Li C, Gajewski MP, Rider KC, Backos DS, Reigan PR, Beall HD, Natale NR. Weaver MJ, et al. Among authors: backos ds. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1765-1770. doi: 10.1016/j.bmcl.2015.02.063. Epub 2015 Mar 3. Bioorg Med Chem Lett. 2015. PMID: 25782743 Free PMC article.

5

10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties.

Weaver MJ, Stump S, Campbell MJ, Backos DS, Li C, Reigan P, Adams E, Beall HD, Natale NR. Weaver MJ, et al. Among authors: backos ds. Bioorg Med Chem. 2020 Nov 15;28(22):115781. doi: 10.1016/j.bmc.2020.115781. Epub 2020 Sep 24. Bioorg Med Chem. 2020. PMID: 33038788 Free PMC article.

6

10-Alkoxy-anthracenyl-isoxazole analogs have sub-micromolar activity against a Glioblastoma multiforme cell line.

Duncan NS, Campbell MJ, Backos DS, Li C, Rider KC, Stump S, Weaver MJ, Gajewski MP, Beall HD, Reigan P, Natale NR. Duncan NS, et al. Among authors: backos ds. Bioorg Med Chem. 2022 Sep 1;69:116911. doi: 10.1016/j.bmc.2022.116911. Epub 2022 Jul 1. Bioorg Med Chem. 2022. PMID: 35792402

7

Selective Targeting of RSK Isoforms in Cancer.

Casalvieri KA, Matheson CJ, Backos DS, Reigan P. Casalvieri KA, et al. Among authors: backos ds. Trends Cancer. 2017 Apr;3(4):302-312. doi: 10.1016/j.trecan.2017.03.004. Epub 2017 Apr 3. Trends Cancer. 2017. PMID: 28718440 Review.

8

The role of glutathione in brain tumor drug resistance.

Backos DS, Franklin CC, Reigan P. Backos DS, et al. Biochem Pharmacol. 2012 Apr 15;83(8):1005-12. doi: 10.1016/j.bcp.2011.11.016. Epub 2011 Nov 28. Biochem Pharmacol. 2012. PMID: 22138445 Review.

9

Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis.

Ryan K, Backos DS, Reigan P, Patel M. Ryan K, et al. Among authors: backos ds. J Neurosci. 2012 Aug 15;32(33):11250-8. doi: 10.1523/JNEUROSCI.0907-12.2012. J Neurosci. 2012. PMID: 22895709 Free PMC article.

10

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

Furtek SL, Backos DS, Matheson CJ, Reigan P. Furtek SL, et al. Among authors: backos ds. ACS Chem Biol. 2016 Feb 19;11(2):308-18. doi: 10.1021/acschembio.5b00945. Epub 2016 Jan 15. ACS Chem Biol. 2016. PMID: 26730496 Review.

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