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A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment.
De Vlieghere E, Van de Vijver K, Blondeel E, Carpentier N, Ghobeira R, Pauwels J, Riemann S, Minsart M, Fieuws C, Mestach J, Baeyens A, De Geyter N, Debbaut C, Denys H, Descamps B, Claes K, Vral A, Van Dorpe J, Gevaert K, De Geest BG, Ceelen W, Van Vlierberghe S, De Wever O. De Vlieghere E, et al. Among authors: de geest bg, de wever o, de geyter n. Biomater Res. 2023 Oct 18;27(1):104. doi: 10.1186/s40824-023-00441-3. Biomater Res. 2023. PMID: 37853495 Free PMC article.
CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity.
Ye T, Zhong Z, Cappellesso F, Deswarte K, Chen Y, Lauwers H, De Lombaerde E, Gontsarik M, Lienenklaus S, Van Lysebetten D, Sanders NN, Lambrecht BN, De Koker S, Laoui D, De Geest BG. Ye T, et al. Among authors: de geest bg. Biomaterials. 2024 Dec;311:122693. doi: 10.1016/j.biomaterials.2024.122693. Epub 2024 Jun 27. Biomaterials. 2024. PMID: 38996672
A Fentanyl Hapten-Displaying Lipid Nanoparticle Vaccine that Non-Covalently Encapsulates a TLR7/8 Agonist and T-Helper Epitope Induces Protective Anti-Fentanyl Immunity.
Zhong Z, Deventer MH, Chen Y, Vanhee S, Lammens I, Deswarte K, Huang Y, Ye T, Wang H, Nuhn L, Vandeputte MM, Gontsarik M, Cui X, Sanders NN, Lienenklaus S, N Lambrecht B, Baptista AP, Stove CP, G De Geest B. Zhong Z, et al. Angew Chem Int Ed Engl. 2024 Oct 23:e202419031. doi: 10.1002/anie.202419031. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39441822
Challenges in neoantigen-directed therapeutics.
Lybaert L, Lefever S, Fant B, Smits E, De Geest B, Breckpot K, Dirix L, Feldman SA, van Criekinge W, Thielemans K, van der Burg SH, Ott PA, Bogaert C. Lybaert L, et al. Cancer Cell. 2023 Jan 9;41(1):15-40. doi: 10.1016/j.ccell.2022.10.013. Epub 2022 Nov 10. Cancer Cell. 2023. PMID: 36368320 Free article. Review.
LXR signaling controls homeostatic dendritic cell maturation.
Bosteels V, Maréchal S, De Nolf C, Rennen S, Maelfait J, Tavernier SJ, Vetters J, Van De Velde E, Fayazpour F, Deswarte K, Lamoot A, Van Duyse J, Martens L, Bosteels C, Roelandt R, Emmaneel A, Van Gassen S, Boon L, Van Isterdael G, Guillas I, Vandamme N, Höglinger D, De Geest BG, Le Goff W, Saeys Y, Ravichandran KS, Lambrecht BN, Janssens S. Bosteels V, et al. Among authors: de nolf c, de geest bg. Sci Immunol. 2023 May 12;8(83):eadd3955. doi: 10.1126/sciimmunol.add3955. Epub 2023 May 12. Sci Immunol. 2023. PMID: 37172103
196 results