Spasov KA - Search Results

1

Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.

Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS. Hollander K, et al. Among authors: spasov ka. Protein Sci. 2023 Dec;32(12):e4814. doi: 10.1002/pro.4814. Protein Sci. 2023. PMID: 37861472 Free PMC article.

2

RAC protein induces enzymatic access to the maturing 3'-end of the 25S rRNA in Schizosaccharomyces pombe.

Spasov K, Nazar RN. Spasov K, et al. Biochem Biophys Res Commun. 2008 Apr 4;368(2):374-8. doi: 10.1016/j.bbrc.2008.01.068. Epub 2008 Jan 24. Biochem Biophys Res Commun. 2008. PMID: 18222117

3

Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB.

Hung KW, Chang YW, Eng ET, Chen JH, Chen YC, Sun YJ, Hsiao CD, Dong G, Spasov KA, Unger VM, Huang TH. Hung KW, et al. Among authors: spasov ka. J Struct Biol. 2010 Jun;170(3):501-12. doi: 10.1016/j.jsb.2010.01.017. Epub 2010 Feb 1. J Struct Biol. 2010. PMID: 20123128 Free PMC article.

4

RAC protein directs the complete removal of the 3' external transcribed spacer by the Pac1 nuclease.

Spasov K, Perdomo LI, Evakine E, Nazar RN. Spasov K, et al. Mol Cell. 2002 Feb;9(2):433-7. doi: 10.1016/s1097-2765(02)00461-6. Mol Cell. 2002. PMID: 11864615 Free article.

5

Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives.

Leung CS, Zeevaart JG, Domaoal RA, Bollini M, Thakur VV, Spasov KA, Anderson KS, Jorgensen WL. Leung CS, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2485-8. doi: 10.1016/j.bmcl.2010.03.006. Epub 2010 Mar 4. Bioorg Med Chem Lett. 2010. PMID: 20304641 Free PMC article.

6

Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase.

Jorgensen WL, Bollini M, Thakur VV, Domaoal RA, Spasov KA, Anderson KS. Jorgensen WL, et al. Among authors: spasov ka. J Am Chem Soc. 2011 Oct 5;133(39):15686-96. doi: 10.1021/ja2058583. Epub 2011 Sep 9. J Am Chem Soc. 2011. PMID: 21853995 Free PMC article.

7

Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents.

Bollini M, Domaoal RA, Thakur VV, Gallardo-Macias R, Spasov KA, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. J Med Chem. 2011 Dec 22;54(24):8582-91. doi: 10.1021/jm201134m. Epub 2011 Nov 29. J Med Chem. 2011. PMID: 22081993 Free PMC article.

8

Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase.

Ekkati AR, Bollini M, Domaoal RA, Spasov KA, Anderson KS, Jorgensen WL. Ekkati AR, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1565-8. doi: 10.1016/j.bmcl.2011.12.132. Epub 2012 Jan 5. Bioorg Med Chem Lett. 2012. PMID: 22269110 Free PMC article.

9

Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency.

Bollini M, Gallardo-Macias R, Spasov KA, Tirado-Rives J, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1110-3. doi: 10.1016/j.bmcl.2012.11.115. Epub 2012 Dec 12. Bioorg Med Chem Lett. 2013. PMID: 23298809 Free PMC article.

10

Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility.

Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5209-12. doi: 10.1016/j.bmcl.2013.06.093. Epub 2013 Jul 8. Bioorg Med Chem Lett. 2013. PMID: 23899617 Free PMC article.

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