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N-Acetylglutamate and N-acetylmethionine compromise mitochondrial bioenergetics homeostasis and glutamate oxidation in brain of developing rats: Potential implications for the pathogenesis of ACY1 deficiency.
Bortoluzzi VT, Ribeiro RT, Pinheiro CV, Castro ET, Tavares TQ, Leipnitz G, Sass JO, Castilho RF, Amaral AU, Wajner M. Bortoluzzi VT, et al. Among authors: pinheiro cv. Biochem Biophys Res Commun. 2023 Dec 3;684:149123. doi: 10.1016/j.bbrc.2023.149123. Epub 2023 Oct 17. Biochem Biophys Res Commun. 2023. PMID: 37871522
In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury.
Zemniaçak ÂB, Ribeiro RT, Pinheiro CV, de Azevedo Cunha S, Tavares TQ, Castro ET, Leipnitz G, Wajner M, Amaral AU. Zemniaçak ÂB, et al. Among authors: pinheiro cv. Mol Neurobiol. 2024 May;61(5):2496-2513. doi: 10.1007/s12035-023-03718-9. Epub 2023 Nov 1. Mol Neurobiol. 2024. PMID: 37910283
Protective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain.
Ribeiro RT, Marcuzzo MB, Carvalho AVS, Palavro R, Castro ET, Pinheiro CV, Bobermin LD, Amaral AU, Leipnitz G, Netto CA, Wajner M. Ribeiro RT, et al. Among authors: pinheiro cv. Eur J Pharmacol. 2025 Jan 15;987:177186. doi: 10.1016/j.ejphar.2024.177186. Epub 2024 Dec 6. Eur J Pharmacol. 2025. PMID: 39647572
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats.
Glänzel NM, da Rosa-Junior NT, Signori MF, de Andrade Silveira J, Pinheiro CV, Marcuzzo MB, Campos-Carraro C, da Rosa Araujo AS, Schiöth HB, Wajner M, Leipnitz G. Glänzel NM, et al. Among authors: pinheiro cv. Metab Brain Dis. 2024 Dec 20;40(1):73. doi: 10.1007/s11011-024-01510-9. Metab Brain Dis. 2024. PMID: 39704910
Preliminary results of PBA-loaded nanoparticles development and the effect on oxidative stress and neuroinflammation in rats submitted to a chemically induced chronic model of MSUD.
Mescka CP, de Moura Coelho D, Sitta A, Catarino F, Donida B, Rosa AP, Gonzalez EA, Pinheiro CV, Poletto F, Baldo G, Dutra-Filho CS, Vargas CR. Mescka CP, et al. Among authors: pinheiro cv. Metab Brain Dis. 2021 Jun;36(5):1015-1027. doi: 10.1007/s11011-021-00686-8. Epub 2021 Feb 23. Metab Brain Dis. 2021. PMID: 33620579
17 results