He Y - Search Results

1

Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders.

He Y, Zhu D, Greenman K, Ruiz C, Shang J, Lu Q, Kojetin DJ, Drakas R, Cameron MD, Lizarzaburu M, Solt LA, Kamenecka TM. He Y, et al. J Med Chem. 2023 Nov 9;66(21):14815-14823. doi: 10.1021/acs.jmedchem.3c01413. Epub 2023 Oct 27. J Med Chem. 2023. PMID: 37888788

2

Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.

Shin Y, Noel R, Banerjee S, Kojetin D, Song X, He Y, Lin L, Cameron MD, Burris TP, Kamenecka TM. Shin Y, et al. Among authors: he y. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4413-7. doi: 10.1016/j.bmcl.2012.04.126. Epub 2012 May 8. Bioorg Med Chem Lett. 2012. PMID: 22633688 Free PMC article.

3

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors.

Noël R, Shin Y, Song X, He Y, Koenig M, Chen W, Ling YY, Lin L, Ruiz CH, LoGrasso P, Cameron MD, Duckett DR, Kamenecka TM. Noël R, et al. Among authors: he y. Bioorg Med Chem Lett. 2011 May 1;21(9):2732-5. doi: 10.1016/j.bmcl.2010.11.104. Epub 2010 Dec 1. Bioorg Med Chem Lett. 2011. PMID: 21185177 Free PMC article.

4

Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.

Solt LA, Kumar N, He Y, Kamenecka TM, Griffin PR, Burris TP. Solt LA, et al. Among authors: he y. ACS Chem Biol. 2012 Sep 21;7(9):1515-9. doi: 10.1021/cb3002649. Epub 2012 Jul 9. ACS Chem Biol. 2012. PMID: 22769242 Free PMC article.

5

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

He Y, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Ruiz CH, Lograsso PV, Kamenecka TM, Koenig M. He Y, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):161-4. doi: 10.1016/j.bmcl.2013.11.052. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332487 Free PMC article.

6

Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.

Asteian A, Blayo AL, He Y, Koenig M, Shin Y, Kuruvilla DS, Corzo CA, Cameron MD, Lin L, Ruiz C, Khan S, Kumar N, Busby S, Marciano DP, Garcia-Ordonez RD, Griffin PR, Kamenecka TM. Asteian A, et al. Among authors: he y. ACS Med Chem Lett. 2015 Aug 4;6(9):998-1003. doi: 10.1021/acsmedchemlett.5b00218. eCollection 2015 Sep 10. ACS Med Chem Lett. 2015. PMID: 26396687 Free PMC article.

7

Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.

Frkic RL, He Y, Rodriguez BB, Chang MR, Kuruvilla D, Ciesla A, Abell AD, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. Among authors: he y. J Med Chem. 2017 Jun 8;60(11):4584-4593. doi: 10.1021/acs.jmedchem.6b01727. Epub 2017 May 22. J Med Chem. 2017. PMID: 28485590 Free PMC article.

8

REV-ERBα Regulates T_H17 Cell Development and Autoimmunity.

Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, Pelletier OB, He Y, Doebelin C, Cameron MD, Kojetin DJ, Kamenecka TM, Solt LA. Amir M, et al. Among authors: he y. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8. doi: 10.1016/j.celrep.2018.11.101. Cell Rep. 2018. PMID: 30590045 Free PMC article.

9

Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α.

Doebelin C, He Y, Campbell S, Nuhant P, Kumar N, Koenig M, Garcia-Ordonez R, Chang MR, Roush WR, Lin L, Kahn S, Cameron MD, Griffin PR, Solt LA, Kamenecka TM. Doebelin C, et al. Among authors: he y. Med Chem. 2019;15(6):676-684. doi: 10.2174/1573406415666190222124745. Med Chem. 2019. PMID: 30799793

10

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

He Y, Kamenecka TM, Shin Y, Song X, Jiang R, Noel R, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Khan S, Koenig M, LoGrasso PV. He Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1719-23. doi: 10.1016/j.bmcl.2011.01.079. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316221 Free PMC article.

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