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KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance.
Zavitsanou AM, Pillai R, Hao Y, Wu WL, Bartnicki E, Karakousi T, Rajalingam S, Herrera A, Karatza A, Rashidfarrokhi A, Solis S, Ciampricotti M, Yeaton AH, Ivanova E, Wohlhieter CA, Buus TB, Hayashi M, Karadal-Ferrena B, Pass HI, Poirier JT, Rudin CM, Wong KK, Moreira AL, Khanna KM, Tsirigos A, Papagiannakopoulos T, Koralov SB. Zavitsanou AM, et al. Among authors: wong kk. Cell Rep. 2023 Nov 28;42(11):113295. doi: 10.1016/j.celrep.2023.113295. Epub 2023 Oct 26. Cell Rep. 2023. PMID: 37889752 Free PMC article.
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T. Pillai R, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jun 28:2023.06.27.546750. doi: 10.1101/2023.06.27.546750. bioRxiv. 2023. Update in: Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859 PMID: 37425844 Free PMC article. Updated. Preprint.
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth.
Rashidfarrokhi A, Pillai R, Hao Y, Wu WL, Karadal-Ferrena B, Dimitriadoy SG, Cross M, Yeaton AH, Huang SM, Bhutkar AJ, Herrera A, Rajalingam S, Hayashi M, Huang KL, Bartnicki E, Zavitsanou AM, Wohlhieter CA, Leboeuf SE, Chen T, Loomis C, Mezzano V, Kulicke R, Davis FP, Stransky N, Smolen GA, Rudin CM, Moreira AL, Khanna KM, Pass HI, Wong KK, Koide S, Tsirigos A, Koralov SB, Papagiannakopoulos T. Rashidfarrokhi A, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jul 17:2023.07.15.549147. doi: 10.1101/2023.07.15.549147. bioRxiv. 2023. PMID: 37502974 Free PMC article. Preprint.
Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy.
Biswas S, Kang K, Ng KP, Radivoyevitch T, Schalper K, Zhang H, Lindner DJ, Thomas A, MacPherson D, Gastman B, Schrump DS, Wong KK, Velcheti V, Saunthararajah Y. Biswas S, et al. Among authors: wong kk. Cell Rep. 2023 Aug 29;42(8):113016. doi: 10.1016/j.celrep.2023.113016. Epub 2023 Aug 18. Cell Rep. 2023. PMID: 37597186 Free PMC article.
Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.
Li D, Geng K, Hao Y, Gu J, Kumar S, Olson AT, Kuismi CC, Kim HM, Pan Y, Sherman F, Williams AM, Li Y, Li F, Chen T, Thakurdin C, Ranieri M, Meynardie M, Levin DS, Stephens J, Chafitz A, Chen J, Donald-Paladino MS, Powell JM, Zhang ZY, Chen W, Ploszaj M, Han H, Gu S, Zhang T, Hu B, Nacev BA, Kaiza ME, Berger AH, Wang X, Li J, Sun X, Liu Y, Zhang X, Bruno TC, Gray NS, Nabet B, Wong KK, Zhang H. Li D, et al. Among authors: wong kk. J Clin Invest. 2024 Dec 24:e174249. doi: 10.1172/JCI174249. Online ahead of print. J Clin Invest. 2024. PMID: 39718828 Free article.
EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas.
DuCote TJ, Song X, Naughton KJ, Chen F, Plaugher DR, Childress AR, Edgin AR, Qu X, Liu J, Liu J, Li F, Wong KK, Brainson CF. DuCote TJ, et al. Among authors: wong kk. bioRxiv [Preprint]. 2023 Jun 8:2023.06.06.543919. doi: 10.1101/2023.06.06.543919. bioRxiv. 2023. Update in: Cancer Res Commun. 2024 Feb 13;4(2):388-403. doi: 10.1158/2767-9764.CRC-23-0399 PMID: 37333199 Free PMC article. Updated. Preprint.
LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.
Compton SE, Kitchen-Goosen SM, DeCamp LM, Lau KH, Mabvakure B, Vos M, Williams KS, Wong KK, Shi X, Rothbart SB, Krawczyk CM, Jones RG. Compton SE, et al. Among authors: wong kk. Mol Cell. 2023 Jun 1;83(11):1872-1886.e5. doi: 10.1016/j.molcel.2023.04.017. Epub 2023 May 11. Mol Cell. 2023. PMID: 37172591 Free article.
FGFR inhibition augments anti-PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression.
Okato A, Utsumi T, Ranieri M, Zheng X, Zhou M, Pereira LD, Chen T, Kita Y, Wu D, Hyun H, Lee H, Gdowski AS, Raupp JD, Clark-Garvey S, Manocha U, Chafitz A, Sherman F, Stephens J, Rose TL, Milowsky MI, Wobker SE, Serody JS, Damrauer JS, Wong KK, Kim WY. Okato A, et al. Among authors: wong kk. J Clin Invest. 2024 Jan 16;134(2):e169241. doi: 10.1172/JCI169241. J Clin Invest. 2024. PMID: 38226620 Free PMC article.
Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.
Li C, Yu Y, Wan Z, Chiu MC, Huang J, Zhang S, Zhu X, Lan Q, Deng Y, Zhou Y, Xue W, Yue M, Cai JP, Yip CC, Wong KK, Liu X, Yu Y, Huang L, Chu H, Chan JF, Clevers H, Yuen KY, Zhou J. Li C, et al. Among authors: wong kk. Nat Commun. 2024 Dec 30;15(1):10772. doi: 10.1038/s41467-024-55076-2. Nat Commun. 2024. PMID: 39738014 Free PMC article.
1,812 results