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Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis.
Zupancic JM, Desai AA, Schardt JS, Pornnoppadol G, Makowski EK, Smith MD, Kennedy AA, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tai AW, Tessier PM. Zupancic JM, et al. Among authors: pornnoppadol g. Cell Chem Biol. 2021 Sep 16;28(9):1379-1388.e7. doi: 10.1016/j.chembiol.2021.05.019. Epub 2021 Jun 24. Cell Chem Biol. 2021. PMID: 34171229 Free PMC article.
Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants.
Zupancic JM, Schardt JS, Desai AA, Makowski EK, Smith MD, Pornnoppadol G, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, Tessier PM. Zupancic JM, et al. Among authors: pornnoppadol g. Adv Ther (Weinh). 2021 Aug;4(8):2100099. doi: 10.1002/adtp.202100099. Epub 2021 Aug 2. Adv Ther (Weinh). 2021. PMID: 34514086 Free PMC article.
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs.
Pornnoppadol G, Bond LG, Lucas MJ, Zupancic JM, Kuo YH, Zhang B, Greineder CF, Tessier PM. Pornnoppadol G, et al. bioRxiv [Preprint]. 2023 Apr 29:2023.04.29.538811. doi: 10.1101/2023.04.29.538811. bioRxiv. 2023. Update in: Cell Chem Biol. 2024 Feb 15;31(2):361-372.e8. doi: 10.1016/j.chembiol.2023.09.008. PMID: 37162883 Free PMC article. Updated. Preprint.