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Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler.
Kousaxidis A, Paoli P, Kovacikova L, Genovese M, Santi A, Stefek M, Petrou A, Nicolaou I. Kousaxidis A, et al. Among authors: santi a. Eur J Med Chem. 2024 Nov 8;281:117035. doi: 10.1016/j.ejmech.2024.117035. Online ahead of print. Eur J Med Chem. 2024. PMID: 39536493
Can letrozole be repurposed for the treatment of visceral leishmaniasis?
Ribeiro JM, Teixeira EdM, Alves LL, Alves ÉAR, Pascoal-Xavier MA, Santi AMM, Oliveira E, Guimarães PPG, Teixeira-Carvalho A, Murta SMF, Peruhype-Magalhães V, Souza-Fagundes EM. Ribeiro JM, et al. Among authors: santi amm. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0075624. doi: 10.1128/aac.00756-24. Epub 2024 Oct 10. Antimicrob Agents Chemother. 2024. PMID: 39387580
Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function.
Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S. Santi A, et al. Sci Signal. 2024 Mar 12;17(827):eade0580. doi: 10.1126/scisignal.ade0580. Epub 2024 Mar 12. Sci Signal. 2024. PMID: 38470957
Chronic lactate exposure promotes cardiomyocyte cytoskeleton remodelling.
Luti S, Militello R, Pinto G, Illiano A, Marzocchini R, Santi A, Becatti M, Amoresano A, Gamberi T, Pellegrino A, Modesti A, Modesti PA. Luti S, et al. Among authors: santi a. Heliyon. 2024 Jan 16;10(2):e24719. doi: 10.1016/j.heliyon.2024.e24719. eCollection 2024 Jan 30. Heliyon. 2024. PMID: 38312589 Free PMC article.
255 results