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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Specker E, Wesolowski R, Schütz A, Matthes S, Mallow K, Wasinska-Kalwa M, Winkler L, Oder A, Alenina N, Pleimes D, von Kries JP, Heinemann U, Bader M, Nazaré M. Specker E, et al. Among authors: winkler l. J Med Chem. 2023 Nov 9;66(21):14866-14896. doi: 10.1021/acs.jmedchem.3c01454. Epub 2023 Oct 31. J Med Chem. 2023. PMID: 37905925
Structure and function of claudins.
Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J, Blasig IE. Krause G, et al. Among authors: winkler l. Biochim Biophys Acta. 2008 Mar;1778(3):631-45. doi: 10.1016/j.bbamem.2007.10.018. Epub 2007 Oct 25. Biochim Biophys Acta. 2008. PMID: 18036336 Free article. Review.
M01 as a novel drug enhancer for specifically targeting the blood-brain barrier.
Breitkreuz-Korff O, Tscheik C, Del Vecchio G, Dithmer S, Walther W, Orthmann A, Wolburg H, Haseloff RF, Schröder L, Blasig IE, Winkler L. Breitkreuz-Korff O, et al. Among authors: winkler l. J Control Release. 2021 Oct 10;338:137-148. doi: 10.1016/j.jconrel.2021.08.014. Epub 2021 Aug 10. J Control Release. 2021. PMID: 34384796 Free article.
Tight junction proteins at the blood-brain barrier: far more than claudin-5.
Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE, Haseloff RF. Berndt P, et al. Among authors: winkler l. Cell Mol Life Sci. 2019 May;76(10):1987-2002. doi: 10.1007/s00018-019-03030-7. Epub 2019 Feb 7. Cell Mol Life Sci. 2019. PMID: 30734065 Free PMC article.
Structure and function of extracellular claudin domains.
Krause G, Winkler L, Piehl C, Blasig I, Piontek J, Müller SL. Krause G, et al. Among authors: winkler l. Ann N Y Acad Sci. 2009 May;1165:34-43. doi: 10.1111/j.1749-6632.2009.04057.x. Ann N Y Acad Sci. 2009. PMID: 19538285
Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins.
Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms HC, Puchkov D, Devraj K, Kaya M, Qin Z, Liebner S, Wolburg H, Andjelkovic AV, Rex A, Blasig IE, Haseloff RF. Winkler L, et al. J Cereb Blood Flow Metab. 2021 Jan;41(1):132-145. doi: 10.1177/0271678X20904687. Epub 2020 Feb 13. J Cereb Blood Flow Metab. 2021. PMID: 32054373 Free PMC article.
248 results