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Bullous pemphigoid induced by IgG targeting type XVII collagen non-NC16A/NC15A extracellular domains is driven by Fc gamma receptor- and complement-mediated effector mechanisms and is ameliorated by neonatal Fc receptor blockade.
Pigors M, Patzelt S, Reichhelm N, Dworschak J, Khil'chenko S, Emtenani S, Bieber K, Hofrichter M, Kamaguchi M, Goletz S, Köhl G, Köhl J, Komorowski L, Probst C, Vanderheyden K, Balbino B, Ludwig RJ, Verheesen P, Schmidt E. Pigors M, et al. Among authors: goletz s. J Pathol. 2024 Feb;262(2):161-174. doi: 10.1002/path.6220. Epub 2023 Nov 6. J Pathol. 2024. PMID: 37929639
Anti-p200 pemphigoid.
Goletz S, Hashimoto T, Zillikens D, Schmidt E. Goletz S, et al. J Am Acad Dermatol. 2014 Jul;71(1):185-91. doi: 10.1016/j.jaad.2014.02.036. Epub 2014 Apr 24. J Am Acad Dermatol. 2014. PMID: 24767733 Review.
Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease.
Heppe EN, Tofern S, Schulze FS, Ishiko A, Shimizu A, Sina C, Zillikens D, Köhl J, Goletz S, Schmidt E. Heppe EN, et al. Among authors: goletz s. J Invest Dermatol. 2017 Aug;137(8):1709-1718. doi: 10.1016/j.jid.2017.03.037. Epub 2017 Apr 26. J Invest Dermatol. 2017. PMID: 28456612 Free article.
Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.
Samavedam UK, Mitschker N, Kasprick A, Bieber K, Schmidt E, Laskay T, Recke A, Goletz S, Vidarsson G, Schulze FS, Armbrust M, Schulze Dieckhoff K, Pas HH, Jonkman MF, Kalies K, Zillikens D, Gupta Y, Ibrahim SM, Ludwig RJ. Samavedam UK, et al. Among authors: goletz s. Front Immunol. 2018 Feb 15;9:249. doi: 10.3389/fimmu.2018.00249. eCollection 2018. Front Immunol. 2018. PMID: 29497423 Free PMC article.
Prospective study in bullous pemphigoid: association of high serum anti-BP180 IgG levels with increased mortality and reduced Karnofsky score.
Holtsche MM, Goletz S, van Beek N, Zillikens D, Benoit S, Harman K, Walton S, English J, Sticherling M, Chapman A, Levell NJ, Groves R, Williams HC, König IR, Schmidt E; members of the BLISTER Study Group. Holtsche MM, et al. Among authors: goletz s. Br J Dermatol. 2018 Oct;179(4):918-924. doi: 10.1111/bjd.16553. Epub 2018 Jul 5. Br J Dermatol. 2018. PMID: 29607480 Clinical Trial.
IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid.
Chakievska L, Holtsche MM, Künstner A, Goletz S, Petersen BS, Thaci D, Ibrahim SM, Ludwig RJ, Franke A, Sadik CD, Zillikens D, Hölscher C, Busch H, Schmidt E. Chakievska L, et al. Among authors: goletz s. J Autoimmun. 2019 Jan;96:104-112. doi: 10.1016/j.jaut.2018.09.003. Epub 2018 Sep 13. J Autoimmun. 2019. PMID: 30219389 Free article.
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