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Page 1
Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M. Rautajoki KJ, et al. Among authors: tiihonen am. Acta Neuropathol Commun. 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. Acta Neuropathol Commun. 2023. PMID: 37932833 Free PMC article.
PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.
Rautajoki KJ, Jaatinen S, Tiihonen AM, Annala M, Vuorinen EM, Kivinen A, Rauhala MJ, Maass KK, Pajtler KW, Yli-Harja O, Helén P, Haapasalo J, Haapasalo H, Zhang W, Nykter M. Rautajoki KJ, et al. Among authors: tiihonen am. Sci Rep. 2022 Aug 18;12(1):14083. doi: 10.1038/s41598-022-14977-2. Sci Rep. 2022. PMID: 35982066 Free PMC article.
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted.
Governa V, de Oliveira KG, Bång-Rudenstam A, Offer S, Cerezo-Magaña M, Li J, Beyer S, Johansson MC, Månsson AS, Edvardsson C, Durmo F, Gustafsson E, Boukredine A, Jeannot P, Schmidt K, Gezelius E, Menard JA, Garza R, Jakobsson J, de Neergaard T, Sundgren PC, Tiihonen AM, Haapasalo H, Rautajoki KJ, Nordenfelt P, Darabi A, Forsberg-Nilsson K, Pietras A, Talbot H, Bengzon J, Belting M. Governa V, et al. Among authors: tiihonen am. Sci Transl Med. 2024 Oct 30;16(771):eadk1168. doi: 10.1126/scitranslmed.adk1168. Epub 2024 Oct 30. Sci Transl Med. 2024. PMID: 39475570
Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer.
Kiviaho A, Eerola SK, Kallio HML, Andersen MK, Hoikka M, Tiihonen AM, Salonen I, Spotbeen X, Giesen A, Parker CTA, Taavitsainen S, Hantula O, Marttinen M, Hermelo I, Ismail M, Midtbust E, Wess M, Devlies W, Sharma A, Krossa S, Häkkinen T, Afyounian E, Vandereyken K, Kint S, Kesseli J, Tolonen T, Tammela TLJ, Viset T, Størkersen Ø, Giskeødegård GF, Rye MB, Murtola T, Erickson A, Latonen L, Bova GS, Mills IG, Joniau S, Swinnen JV, Voet T, Mirtti T, Attard G, Claessens F, Visakorpi T, Rautajoki KJ, Tessem MB, Urbanucci A, Nykter M. Kiviaho A, et al. Among authors: tiihonen am. Nat Commun. 2024 Nov 16;15(1):9949. doi: 10.1038/s41467-024-54364-1. Nat Commun. 2024. PMID: 39550375 Free PMC article.
Unsupervised clustering reveals noncanonical myeloid cell subsets in the brain tumor microenvironment.
Hermelo I, Virtanen T, Salonen I, Nätkin R, Keitaanniemi S, Tiihonen AM, Lehtipuro S, Kummola L, Raulamo E, Nordfors K, Haapasalo H, Rauhala M, Kesseli J, Nykter M, Haapasalo J, Rautajoki K. Hermelo I, et al. Among authors: tiihonen am. Cancer Immunol Immunother. 2025 Jan 3;74(2):63. doi: 10.1007/s00262-024-03920-1. Cancer Immunol Immunother. 2025. PMID: 39751910 Free PMC article.