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Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA. Hughson AL, et al. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564833. doi: 10.1101/2023.10.30.564833. bioRxiv. 2023. PMID: 37961513 Free PMC article. Preprint.
New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Gerber S, Uccello T, Lesch M, Kintzel S, Gradzewicz L, Lamrous L, Murphy S, Fleming F, Mills B, Murphy J, Hughson A, Garrett-Larsen J, Qiu H, Drage M, Ye J, Gavras N, Keeley D, Love T, Repasky E, Lord E, Linehan D. Gerber S, et al. Res Sq [Preprint]. 2023 Apr 13:rs.3.rs-2767780. doi: 10.21203/rs.3.rs-2767780/v1. Res Sq. 2023. Update in: Cell Death Dis. 2023 Jul 26;14(7):470. doi: 10.1038/s41419-023-05999-3 PMID: 37090639 Free PMC article. Updated. Preprint.
Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer.
Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA. Hughson AL, et al. Mol Ther Nucleic Acids. 2024 Sep 30;35(4):102350. doi: 10.1016/j.omtn.2024.102350. eCollection 2024 Dec 10. Mol Ther Nucleic Acids. 2024. PMID: 39469666 Free PMC article.