Chan WL - Search Results

1

Single-cell, whole-embryo phenotyping of mammalian developmental disorders.

Huang X, Henck J, Qiu C, Sreenivasan VKA, Balachandran S, Amarie OV, Hrabě de Angelis M, Behncke RY, Chan WL, Despang A, Dickel DE, Duran M, Feuchtinger A, Fuchs H, Gailus-Durner V, Haag N, Hägerling R, Hansmeier N, Hennig F, Marshall C, Rajderkar S, Ringel A, Robson M, Saunders LM, da Silva-Buttkus P, Spielmann N, Srivatsan SR, Ulferts S, Wittler L, Zhu Y, Kalscheuer VM, Ibrahim DM, Kurth I, Kornak U, Visel A, Pennacchio LA, Beier DR, Trapnell C, Cao J, Shendure J, Spielmann M. Huang X, et al. Among authors: chan wl. Nature. 2023 Nov;623(7988):772-781. doi: 10.1038/s41586-023-06548-w. Epub 2023 Nov 15. Nature. 2023. PMID: 37968388 Free PMC article.

2

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice.

Kraft K, Geuer S, Will AJ, Chan WL, Paliou C, Borschiwer M, Harabula I, Wittler L, Franke M, Ibrahim DM, Kragesteen BK, Spielmann M, Mundlos S, Lupiáñez DG, Andrey G. Kraft K, et al. Among authors: chan wl. Cell Rep. 2015 Feb 10;10(5):833-839. doi: 10.1016/j.celrep.2015.01.016. Epub 2015 Feb 7. Cell Rep. 2015. PMID: 25660031 Free article.

3

Formation of new chromatin domains determines pathogenicity of genomic duplications.

Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, Kraft K, Kempfer R, Jerković I, Chan WL, Spielmann M, Timmermann B, Wittler L, Kurth I, Cambiaso P, Zuffardi O, Houge G, Lambie L, Brancati F, Pombo A, Vingron M, Spitz F, Mundlos S. Franke M, et al. Among authors: chan wl. Nature. 2016 Oct 13;538(7624):265-269. doi: 10.1038/nature19800. Epub 2016 Oct 5. Nature. 2016. PMID: 27706140

4

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).

Will AJ, Cova G, Osterwalder M, Chan WL, Wittler L, Brieske N, Heinrich V, de Villartay JP, Vingron M, Klopocki E, Visel A, Lupiáñez DG, Mundlos S. Will AJ, et al. Among authors: chan wl. Nat Genet. 2017 Oct;49(10):1539-1545. doi: 10.1038/ng.3939. Epub 2017 Aug 28. Nat Genet. 2017. PMID: 28846100 Free PMC article.

5

Examining tissue composition, whole-bone morphology and mechanical behavior of Gorab^Prx1 mice tibiae: A mouse model of premature aging.

Yang H, Albiol L, Chan WL, Wulsten D, Seliger A, Thelen M, Thiele T, Spevak L, Boskey A, Kornak U, Checa S, Willie BM. Yang H, et al. Among authors: chan wl. J Biomech. 2017 Dec 8;65:145-153. doi: 10.1016/j.jbiomech.2017.10.018. Epub 2017 Oct 25. J Biomech. 2017. PMID: 29108851 Free PMC article.

6

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.

Kragesteen BK, Spielmann M, Paliou C, Heinrich V, Schöpflin R, Esposito A, Annunziatella C, Bianco S, Chiariello AM, Jerković I, Harabula I, Guckelberger P, Pechstein M, Wittler L, Chan WL, Franke M, Lupiáñez DG, Kraft K, Timmermann B, Vingron M, Visel A, Nicodemi M, Mundlos S, Andrey G. Kragesteen BK, et al. Among authors: chan wl. Nat Genet. 2018 Oct;50(10):1463-1473. doi: 10.1038/s41588-018-0221-x. Epub 2018 Sep 27. Nat Genet. 2018. PMID: 30262816 Free PMC article.

7

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation.

Witkos TM, Chan WL, Joensuu M, Rhiel M, Pallister E, Thomas-Oates J, Mould AP, Mironov AA, Biot C, Guerardel Y, Morelle W, Ungar D, Wieland FT, Jokitalo E, Tassabehji M, Kornak U, Lowe M. Witkos TM, et al. Among authors: chan wl. Nat Commun. 2019 Jan 10;10(1):127. doi: 10.1038/s41467-018-08044-6. Nat Commun. 2019. PMID: 30631079 Free PMC article.

8

Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.

Despang A, Schöpflin R, Franke M, Ali S, Jerković I, Paliou C, Chan WL, Timmermann B, Wittler L, Vingron M, Mundlos S, Ibrahim DM. Despang A, et al. Among authors: chan wl. Nat Genet. 2019 Aug;51(8):1263-1271. doi: 10.1038/s41588-019-0466-z. Epub 2019 Jul 29. Nat Genet. 2019. PMID: 31358994 Free article.

9

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.

Allou L, Balzano S, Magg A, Quinodoz M, Royer-Bertrand B, Schöpflin R, Chan WL, Speck-Martins CE, Carvalho DR, Farage L, Lourenço CM, Albuquerque R, Rajagopal S, Nampoothiri S, Campos-Xavier B, Chiesa C, Niel-Bütschi F, Wittler L, Timmermann B, Spielmann M, Robson MI, Ringel A, Heinrich V, Cova G, Andrey G, Prada-Medina CA, Pescini-Gobert R, Unger S, Bonafé L, Grote P, Rivolta C, Mundlos S, Superti-Furga A. Allou L, et al. Among authors: chan wl. Nature. 2021 Apr;592(7852):93-98. doi: 10.1038/s41586-021-03208-9. Epub 2021 Feb 10. Nature. 2021. PMID: 33568816

10

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.

Weinert S, Jabs S, Hohensee S, Chan WL, Kornak U, Jentsch TJ. Weinert S, et al. Among authors: chan wl. EMBO Rep. 2014 Jul;15(7):784-91. doi: 10.15252/embr.201438553. Epub 2014 May 12. EMBO Rep. 2014. PMID: 24820037 Free PMC article.

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