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455 results

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Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly.
Shi X, Lingerak R, Herting CJ, Ge Y, Kim S, Toth P, Wang W, Brown BP, Meiler J, Sossey-Alaoui K, Buck M, Himanen J, Hambardzumyan D, Nikolov DB, Smith AW, Wang B. Shi X, et al. Among authors: meiler j. Science. 2023 Dec;382(6674):1042-1050. doi: 10.1126/science.adg5314. Epub 2023 Nov 16. Science. 2023. PMID: 37972196 Free PMC article.
Lipocalin Blc is a potential heme-binding protein.
Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J. Bozhanova NG, et al. Among authors: meiler j. FEBS Lett. 2021 Jan;595(2):206-219. doi: 10.1002/1873-3468.14001. Epub 2020 Dec 3. FEBS Lett. 2021. PMID: 33210733 Free PMC article.
Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting.
Du Z, Brown BP, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, Red-Brewer M, Ali SM, Schrock AB, Zehir A, Ladanyi M, Smith AW, Meiler J, Lovly CM. Du Z, et al. Among authors: meiler j. Nat Commun. 2021 Mar 2;12(1):1382. doi: 10.1038/s41467-021-21613-6. Nat Commun. 2021. PMID: 33654076 Free PMC article.
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity.
Hanker AB, Brown BP, Meiler J, Marín A, Jayanthan HS, Ye D, Lin CC, Akamatsu H, Lee KM, Chatterjee S, Sudhan DR, Servetto A, Brewer MR, Koch JP, Sheehan JH, He J, Lalani AS, Arteaga CL. Hanker AB, et al. Among authors: meiler j. Cancer Cell. 2021 Aug 9;39(8):1099-1114.e8. doi: 10.1016/j.ccell.2021.06.001. Epub 2021 Jun 24. Cancer Cell. 2021. PMID: 34171264 Free PMC article.
Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery.
Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW Jr, Mueller R, Pape R, Mendenhall J, Meiler J. Brown BP, et al. Among authors: meiler j. Front Pharmacol. 2022 Feb 21;13:833099. doi: 10.3389/fphar.2022.833099. eCollection 2022. Front Pharmacol. 2022. PMID: 35264967 Free PMC article.
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer.
Brown BP, Zhang YK, Kim S, Finneran P, Yan Y, Du Z, Kim J, Hartzler AL, LeNoue-Newton ML, Smith AW, Meiler J, Lovly CM. Brown BP, et al. Among authors: meiler j. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2206588119. doi: 10.1073/pnas.2206588119. Epub 2022 Jul 22. Proc Natl Acad Sci U S A. 2022. PMID: 35867821 Free PMC article.
455 results