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Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors.
Di Stefano M, Masoni S, Bononi G, Poli G, Galati S, Gado F, Manzi S, Vagaggini C, Brai A, Caligiuri I, Asif K, Rizzolio F, Macchia M, Chicca A, Sodi A, Di Bussolo V, Minutolo F, Meier P, Gertsch J, Granchi C, Dreassi E, Tuccinardi T. Di Stefano M, et al. Among authors: brai a. Eur J Med Chem. 2024 Jan 5;263:115916. doi: 10.1016/j.ejmech.2023.115916. Epub 2023 Nov 2. Eur J Med Chem. 2024. PMID: 37976705 Free article.
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules.
Tintori C, Corona A, Esposito F, Brai A, Grandi N, Ceresola ER, Clementi M, Canducci F, Tramontano E, Botta M. Tintori C, et al. Among authors: brai a. Chembiochem. 2016 Apr 15;17(8):683-8. doi: 10.1002/cbic.201500668. Epub 2016 Mar 21. Chembiochem. 2016. PMID: 26946324
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family.
Tintori C, Brai A, Dasso Lang MC, Deodato D, Greco AM, Bizzarri BM, Cascone L, Casian A, Zamperini C, Dreassi E, Crespan E, Maga G, Vanham G, Ceresola E, Canducci F, Ariën KK, Botta M. Tintori C, et al. Among authors: brai a. J Med Chem. 2016 Mar 24;59(6):2747-59. doi: 10.1021/acs.jmedchem.5b01979. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26898379 Free article.
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.
Tintori C, Iovenitti G, Ceresola ER, Ferrarese R, Zamperini C, Brai A, Poli G, Dreassi E, Cagno V, Lembo D, Canducci F, Botta M. Tintori C, et al. Among authors: brai a. PLoS One. 2018 Jun 5;13(6):e0198478. doi: 10.1371/journal.pone.0198478. eCollection 2018. PLoS One. 2018. PMID: 29870553 Free PMC article.
Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor.
Brai A, Boccuto A, Monti M, Marchi S, Vicenti I, Saladini F, Trivisani CI, Pollutri A, Trombetta CM, Montomoli E, Riva V, Garbelli A, Nola EM, Zazzi M, Maga G, Dreassi E, Botta M. Brai A, et al. ACS Med Chem Lett. 2020 Apr 9;11(5):956-962. doi: 10.1021/acsmedchemlett.9b00681. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435411 Free PMC article.
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
Brai A, Riva V, Saladini F, Zamperini C, Trivisani CI, Garbelli A, Pennisi C, Giannini A, Boccuto A, Bugli F, Martini M, Sanguinetti M, Zazzi M, Dreassi E, Botta M, Maga G. Brai A, et al. Eur J Med Chem. 2020 Aug 15;200:112319. doi: 10.1016/j.ejmech.2020.112319. Epub 2020 May 7. Eur J Med Chem. 2020. PMID: 32446036 Free article.
39 results