Le Hégarat L - Search Results

1

Combined in silico and in vitro approaches to identify P-glycoprotein-inhibiting pesticides.

Guéniche N, Lakehal Z, Habauzit D, Bruyère A, Fardel O, Le Hégarat L, Huguet A. Guéniche N, et al. Among authors: le hegarat l. J Biochem Mol Toxicol. 2024 Jan;38(1):e23588. doi: 10.1002/jbt.23588. Epub 2023 Nov 20. J Biochem Mol Toxicol. 2024. PMID: 37985955

2

Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.

Valentin-Severin I, Le Hegarat L, Lhuguenot JC, Le Bon AM, Chagnon MC. Valentin-Severin I, et al. Among authors: le bon am, le hegarat l. Mutat Res. 2003 Apr 20;536(1-2):79-90. doi: 10.1016/s1383-5718(03)00031-7. Mutat Res. 2003. PMID: 12694748

3

In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.

Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, Kasamatsu T, Kojima H, Ouédraogo G, Scott A, Speit G. Pfuhler S, et al. Among authors: le hegarat l. Mutat Res. 2011 Aug 16;723(2):101-7. doi: 10.1016/j.mrgentox.2011.03.013. Epub 2011 Apr 5. Mutat Res. 2011. PMID: 21473931

4

A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes.

Aliche-Djoudi F, Podechard N, Collin A, Chevanne M, Provost E, Poul M, Le Hégarat L, Catheline D, Legrand P, Dimanche-Boitrel MT, Lagadic-Gossmann D, Sergent O. Aliche-Djoudi F, et al. Among authors: le hegarat l. Food Chem Toxicol. 2013 Oct;60:286-96. doi: 10.1016/j.fct.2013.07.061. Epub 2013 Jul 29. Food Chem Toxicol. 2013. PMID: 23907024 Free article.

5

Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450.

Alarcan J, Dubreil E, Huguet A, Hurtaud-Pessel D, Hessel-Pras S, Lampen A, Fessard V, Le Hegarat L. Alarcan J, et al. Among authors: le hegarat l. Toxins (Basel). 2017 Jul 5;9(7):212. doi: 10.3390/toxins9070212. Toxins (Basel). 2017. PMID: 28678150 Free PMC article.

6

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Alarcan J, Dubreil E, Huguet A, Aráoz R, Brée F, Bouaita B, Hurtaud-Pessel D, Braeuning A, Hessel-Pras S, Lampen A, Le Hégarat L, Fessard V. Alarcan J, et al. Among authors: le hegarat l. Toxicol Lett. 2019 Jun 1;307:17-25. doi: 10.1016/j.toxlet.2019.02.012. Epub 2019 Feb 27. Toxicol Lett. 2019. PMID: 30825503

7

Identification of key pathways involved in the toxic response of the cyanobacterial toxin cylindrospermopsin in human hepatic HepaRG cells.

Huguet A, Lanceleur R, Quenault H, Le Hégarat L, Fessard V. Huguet A, et al. Among authors: le hegarat l. Toxicol In Vitro. 2019 Aug;58:69-77. doi: 10.1016/j.tiv.2019.03.023. Epub 2019 Mar 21. Toxicol In Vitro. 2019. PMID: 30905859

8

Differential interactions of carbamate pesticides with drug transporters.

Guéniche N, Bruyere A, Ringeval M, Jouan E, Huguet A, Le Hégarat L, Fardel O. Guéniche N, et al. Among authors: le hegarat l. Xenobiotica. 2020 Nov;50(11):1380-1392. doi: 10.1080/00498254.2020.1771473. Epub 2020 Jun 4. Xenobiotica. 2020. PMID: 32421406 Free article.

9

Comparative in silico prediction of P-glycoprotein-mediated transport for 2010-2020 US FDA-approved drugs using six Web-tools.

Guéniche N, Huguet A, Bruyere A, Habauzit D, Le Hégarat L, Fardel O. Guéniche N, et al. Among authors: le hegarat l. Biopharm Drug Dispos. 2021 Sep;42(8):393-398. doi: 10.1002/bdd.2299. Epub 2021 Aug 6. Biopharm Drug Dispos. 2021. PMID: 34272891

10

The PERICLES research program: an integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed.

Crépet A, Héraud F, Béchaux C, Gouze ME, Pierlot S, Fastier A, Leblanc JCh, Le Hégarat L, Takakura N, Fessard V, Tressou J, Maximilien R, de Sousa G, Nawaz A, Zucchini-Pascal N, Rahmani R, Audebert M, Graillot V, Cravedi JP. Crépet A, et al. Among authors: le hegarat l. Toxicology. 2013 Nov 16;313(2-3):83-93. doi: 10.1016/j.tox.2013.04.005. Epub 2013 Apr 16. Toxicology. 2013. PMID: 23603198

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