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Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Samer S, et al. Among authors: cicala c. JCI Insight. 2023 Nov 22;8(22):e176882. doi: 10.1172/jci.insight.176882. JCI Insight. 2023. PMID: 37991025 Free PMC article. No abstract available.
The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.
Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS. Arthos J, et al. Among authors: cicala c. Curr HIV/AIDS Rep. 2018 Apr;15(2):127-135. doi: 10.1007/s11904-018-0382-3. Curr HIV/AIDS Rep. 2018. PMID: 29478152 Free PMC article. Review.
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.
Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J. Lertjuthaporn S, et al. Among authors: cicala c. PLoS Pathog. 2018 Aug 28;14(8):e1007278. doi: 10.1371/journal.ppat.1007278. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30153309 Free PMC article.
Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.
Calenda G, Frank I, Arrode-Brusés G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E. Calenda G, et al. Among authors: cicala c. PLoS Pathog. 2019 May 13;15(5):e1007776. doi: 10.1371/journal.ppat.1007776. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31083697 Free PMC article.
Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.
Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY, Geng H, Liu C, Zhou T, Kwong PD, Arthos J, Cicala C, Grasperge BF, Blanchard JL, Gettie A, Fennessey CM, Keele BF, Vaccari M, Hope TJ, Fauci AS, Mascola JR, Martinelli E. Frank I, et al. Among authors: cicala c. Sci Transl Med. 2021 Aug 18;13(607):eabf7201. doi: 10.1126/scitranslmed.abf7201. Sci Transl Med. 2021. PMID: 34408080 Free PMC article.
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Samer S, et al. Among authors: cicala c. JCI Insight. 2022 Nov 8;7(21):e162290. doi: 10.1172/jci.insight.162290. JCI Insight. 2022. PMID: 36125890 Free PMC article.
TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo.
Kime J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Marinelli E. Kime J, et al. Among authors: cicala c. bioRxiv [Preprint]. 2023 Dec 15:2023.09.05.556422. doi: 10.1101/2023.09.05.556422. bioRxiv. 2023. Update in: Nat Commun. 2024 Feb 14;15(1):1348. doi: 10.1038/s41467-024-45555-x PMID: 38014094 Free PMC article. Updated. Preprint.
197 results