Begley TJ - Search Results

1

Molecular Coping Mechanisms: Reprogramming tRNAs To Regulate Codon-Biased Translation of Stress Response Proteins.

Mitchener MM, Begley TJ, Dedon PC. Mitchener MM, et al. Among authors: begley tj. Acc Chem Res. 2023 Dec 5;56(23):3504-3514. doi: 10.1021/acs.accounts.3c00572. Epub 2023 Nov 22. Acc Chem Res. 2023. PMID: 37992267 Free PMC article.

2

The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.

Fry RC, DeMott MS, Cosgrove JP, Begley TJ, Samson LD, Dedon PC. Fry RC, et al. Among authors: begley tj. BMC Genomics. 2006 Dec 12;7:313. doi: 10.1186/1471-2164-7-313. BMC Genomics. 2006. PMID: 17163986 Free PMC article.

3

Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.

Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD. Fu D, et al. Among authors: begley tj, begley u. Mol Cell Biol. 2010 May;30(10):2449-59. doi: 10.1128/MCB.01604-09. Epub 2010 Mar 22. Mol Cell Biol. 2010. PMID: 20308323 Free PMC article.

4

A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress.

Chan CT, Dyavaiah M, DeMott MS, Taghizadeh K, Dedon PC, Begley TJ. Chan CT, et al. Among authors: begley tj. PLoS Genet. 2010 Dec 16;6(12):e1001247. doi: 10.1371/journal.pgen.1001247. PLoS Genet. 2010. PMID: 21187895 Free PMC article.

5

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins.

Chan CT, Pang YL, Deng W, Babu IR, Dyavaiah M, Begley TJ, Dedon PC. Chan CT, et al. Among authors: begley tj. Nat Commun. 2012 Jul 3;3:937. doi: 10.1038/ncomms1938. Nat Commun. 2012. PMID: 22760636 Free PMC article.

6

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications.

Patil A, Chan CT, Dyavaiah M, Rooney JP, Dedon PC, Begley TJ. Patil A, et al. Among authors: begley tj. RNA Biol. 2012 Jul;9(7):990-1001. doi: 10.4161/rna.20531. Epub 2012 Jul 1. RNA Biol. 2012. PMID: 22832247 Free PMC article.

7

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response.

Patil A, Dyavaiah M, Joseph F, Rooney JP, Chan CT, Dedon PC, Begley TJ. Patil A, et al. Among authors: begley tj. Cell Cycle. 2012 Oct 1;11(19):3656-65. doi: 10.4161/cc.21919. Epub 2012 Aug 30. Cell Cycle. 2012. PMID: 22935709 Free PMC article.

8

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.

Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CT, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T. Begley U, et al. EMBO Mol Med. 2013 Mar;5(3):366-83. doi: 10.1002/emmm.201201161. Epub 2013 Feb 4. EMBO Mol Med. 2013. PMID: 23381944 Free PMC article.

9

A system of RNA modifications and biased codon use controls cellular stress response at the level of translation.

Dedon PC, Begley TJ. Dedon PC, et al. Among authors: begley tj. Chem Res Toxicol. 2014 Mar 17;27(3):330-7. doi: 10.1021/tx400438d. Epub 2014 Jan 27. Chem Res Toxicol. 2014. PMID: 24422464 Free PMC article.

10

Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry.

Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC. Su D, et al. Among authors: begley tj. Nat Protoc. 2014 Apr;9(4):828-41. doi: 10.1038/nprot.2014.047. Epub 2014 Mar 13. Nat Protoc. 2014. PMID: 24625781 Free PMC article.

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