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Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.
Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM. Tauriello DV, et al. Among authors: maurice mm. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20. doi: 10.1073/pnas.1114802109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411803 Free PMC article.
Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling.
Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Han JK, Lee MJ, Finley D, Jho EH. Jung H, et al. Among authors: maurice mm. Oncogenesis. 2013 Aug 19;2(8):e64. doi: 10.1038/oncsis.2013.28. Oncogenesis. 2013. PMID: 23958854 Free PMC article.
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. Anvarian Z, et al. Among authors: maurice mm. Nat Struct Mol Biol. 2016 Apr;23(4):324-32. doi: 10.1038/nsmb.3191. Epub 2016 Mar 14. Nat Struct Mol Biol. 2016. PMID: 26974125
TMEM59 potentiates Wnt signaling by promoting signalosome formation.
Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM. Gerlach JP, et al. Among authors: maurice mm. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9. Proc Natl Acad Sci U S A. 2018. PMID: 29632210 Free PMC article.
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM. Fenderico N, et al. Among authors: maurice mm. Nat Commun. 2019 Jan 21;10(1):365. doi: 10.1038/s41467-018-08172-z. Nat Commun. 2019. PMID: 30664649 Free PMC article.
70 results