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Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative.
Wyse RK, Isaacs T, Barker RA, Cookson MR, Dawson TM, Devos D, Dexter DT, Duffen J, Federoff H, Fiske B, Foltynie T, Fox S, Greenamyre JT, Kieburtz K, Kordower JH, Krainc D, Matthews H, Moore DJ, Mursaleen L, Schwarzschild MA, Stott SRW, Sulzer D, Svenningsson P, Tanner CM, Carroll C, Simon DK, Brundin P. Wyse RK, et al. Among authors: kordower jh. J Parkinsons Dis. 2024;14(4):657-666. doi: 10.3233/JPD-230363. J Parkinsons Dis. 2024. PMID: 38578902 Free PMC article. Review.
Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.
Corbin-Stein NJ, Childers GM, Webster JM, Zane A, Yang YT, Ali MA, Sandoval IM, Manfredsson FP, Kordower JH, Tyrrell DJ, Harms AS. Corbin-Stein NJ, et al. Among authors: kordower jh. bioRxiv [Preprint]. 2024 Jun 3:2024.06.02.597035. doi: 10.1101/2024.06.02.597035. bioRxiv. 2024. PMID: 38895456 Free PMC article. Preprint.
Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs.
Kasanga EA, Han Y, Shifflet MK, Navarrete W, McManus R, Parry C, Barahona A, Nejtek VA, Manfredsson FP, Kordower JH, Richardson JR, Salvatore MF. Kasanga EA, et al. Among authors: kordower jh. Exp Neurol. 2023 Oct;368:114509. doi: 10.1016/j.expneurol.2023.114509. Epub 2023 Aug 25. Exp Neurol. 2023. PMID: 37634696
Alpha-synuclein aggregates are phosphatase resistant.
Choi SG, Tittle T, Garcia-Prada D, Kordower JH, Melki R, Killinger BA. Choi SG, et al. Among authors: kordower jh. Acta Neuropathol Commun. 2024 May 31;12(1):84. doi: 10.1186/s40478-024-01785-0. Acta Neuropathol Commun. 2024. PMID: 38822421 Free PMC article.
Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.
Walton S, Fenyi A, Tittle T, Sidransky E, Pal G, Choi S, Melki R, Killinger BA, Kordower JH. Walton S, et al. Among authors: kordower jh. bioRxiv [Preprint]. 2023 Aug 25:2023.08.24.554646. doi: 10.1101/2023.08.24.554646. bioRxiv. 2023. PMID: 37662402 Free PMC article. Preprint.
International Parkinson and Movement Disorder Society Viewpoint on Biological Frameworks of Parkinson's Disease: Current Status and Future Directions.
Kalia LV, Berg D, Kordower JH, Shannon KM, Taylor JP, Cardoso F, Goldman JG, Jeon B, Meissner WG, Tijssen MAJ, Burn DJ, Fung VSC. Kalia LV, et al. Among authors: kordower jh. Mov Disord. 2024 Oct;39(10):1710-1715. doi: 10.1002/mds.30007. Epub 2024 Sep 9. Mov Disord. 2024. PMID: 39250594 No abstract available.
367 results