Misehe M - Search Results

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Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.

Misehe M, Šála M, Matoušová M, Hercík K, Kocek H, Chalupská D, Chaloupecká E, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R. Misehe M, et al. Bioorg Med Chem Lett. 2024 Jan 1;97:129567. doi: 10.1016/j.bmcl.2023.129567. Epub 2023 Nov 24. Bioorg Med Chem Lett. 2024. PMID: 38008339 Free article.

Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.

Misehe M, Matoušová M, Dvořáková A, Hercík K, Škach K, Chalupská D, Dejmek M, Šála M, Hájek M, Boura E, Mertlíková-Kaiserová H, Nencka R. Misehe M, et al. Eur J Med Chem. 2023 Nov 15;260:115717. doi: 10.1016/j.ejmech.2023.115717. Epub 2023 Aug 9. Eur J Med Chem. 2023. PMID: 37598483 Free article.

Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.

Misehe M, Klima M, Matoušová M, Chalupská D, Dejmek M, Šála M, Mertlíková-Kaiserová H, Boura E, Nencka R. Misehe M, et al. Bioorg Med Chem Lett. 2022 Nov 15;76:129010. doi: 10.1016/j.bmcl.2022.129010. Epub 2022 Sep 29. Bioorg Med Chem Lett. 2022. PMID: 36184029

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