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New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies.
Fadaly WAA, Zidan TH, Kahk NM, Mohamed FEA, Abdelhakeem MM, Khalil RG, Nemr MTM. Fadaly WAA, et al. Among authors: abdelhakeem mm. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2281262. doi: 10.1080/14756366.2023.2281262. Epub 2023 Nov 27. J Enzyme Inhib Med Chem. 2023. PMID: 38010912 Free PMC article.
New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies.
Abdellatif KRA, Abdelall EKA, Lamie PF, Labib MB, El-Nahaas ES, Abdelhakeem MM. Abdellatif KRA, et al. Among authors: abdelhakeem mm. Bioorg Chem. 2020 Jan;95:103540. doi: 10.1016/j.bioorg.2019.103540. Epub 2019 Dec 23. Bioorg Chem. 2020. PMID: 31911297
New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study.
Fadaly WAA, Nemr MTM, Zidan TH, Mohamed FEA, Abdelhakeem MM, Abu Jayab NN, Omar HA, Abdellatif KRA. Fadaly WAA, et al. Among authors: abdelhakeem mm. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2290461. doi: 10.1080/14756366.2023.2290461. Epub 2023 Dec 7. J Enzyme Inhib Med Chem. 2023. PMID: 38061801 Free PMC article.
Natural Immunomodulators Treat the Cytokine Storm in SARS-CoV-2.
Abbas HS, Abd-Elhakeem MM, Abd El Galil RM, Reyad OA, Mohamed HA, Ismail SES, Nabil MA. Abbas HS, et al. Adv Pharm Bull. 2023 Jan;13(1):79-87. doi: 10.34172/apb.2023.006. Epub 2021 Oct 2. Adv Pharm Bull. 2023. PMID: 36721816 Free PMC article. Review.