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Page 1
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker B, Gardner M, Guinn KM, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Nov 19:2023.11.19.567569. doi: 10.1101/2023.11.19.567569. bioRxiv. 2023. PMID: 38014062 Free PMC article. Preprint.
Protective intravenous BCG vaccination induces enhanced immune signaling in the airways.
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, Fortune SM, Bryson BD. Peters JM, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Jul 18:2023.07.16.549208. doi: 10.1101/2023.07.16.549208. bioRxiv. 2023. PMID: 37502895 Free PMC article. Preprint.
CD4+ T cells are homeostatic regulators during Mtb reinfection.
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang D, Rosenberg JM, Klein EC, Gideon HP, Floyd-O'Sullivan R, Berger B, Scanga CA, Lin PL, Fortune SM, Shalek AK, Flynn JL. Bromley JD, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2023 Dec 21:2023.12.20.572669. doi: 10.1101/2023.12.20.572669. bioRxiv. 2023. PMID: 38187598 Free PMC article. Preprint.
Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaques.
Ganchua SK, Maiello P, Chao M, Hopkins F, Mugahid D, Lin PL, Fortune SM, Flynn JL. Ganchua SK, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2024 Feb 24:2023.12.19.570845. doi: 10.1101/2023.12.19.570845. bioRxiv. 2024. Update in: Infect Immun. 2024 Apr 9;92(4):e0053523. doi: 10.1128/iai.00535-23. PMID: 38187678 Free PMC article. Updated. Preprint.
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques.
Simonson AW, Zeppa JJ, Bucsan AN, Chao MC, Pokkali S, Hopkins F, Chase MR, Vickers AJ, Sutton MS, Winchell CG, Myers AJ, Ameel CL, Kelly R, Krouse B, Hood LE, Li J, Lehman CC, Kamath M, Tomko J, Rodgers MA, Donlan R, Chishti H, Jacob Borish H, Klein E, Scanga CA, Fortune S, Lin PL, Maiello P, Roederer M, Darrah PA, Seder RA, Flynn JL. Simonson AW, et al. bioRxiv [Preprint]. 2024 May 17:2024.05.14.594183. doi: 10.1101/2024.05.14.594183. bioRxiv. 2024. PMID: 38798646 Free PMC article. Preprint.
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
Grace PS, Peters JM, Sixsmith J, Lu R, Luedeman C, Fenderson BA, Vickers A, Slein MD, Irvine EB, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sasseti CM, Bryson BD, Fortune SM, Alter G. Grace PS, et al. Among authors: fortune sm. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617070. doi: 10.1101/2024.10.07.617070. bioRxiv. 2024. PMID: 39416184 Free PMC article. Preprint.
Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.
Wang S, Myers AJ, Irvine EB, Wang C, Maiello P, Rodgers MA, Tomko J, Kracinovsky K, Borish HJ, Chao MC, Mugahid D, Darrah PA, Seder RA, Roederer M, Scanga CA, Lin PL, Alter G, Fortune SM, Flynn JL, Lauffenburger DA. Wang S, et al. Among authors: fortune sm. Cell Syst. 2024 Oct 29:S2405-4712(24)00298-9. doi: 10.1016/j.cels.2024.10.001. Online ahead of print. Cell Syst. 2024. PMID: 39504969
Vaginal lactobacilli produce anti-inflammatory β-carboline compounds.
Glick VJ, Webber CA, Simmons LE, Martin MC, Ahmad M, Kim CH, Adams AND, Bang S, Chao MC, Howard NC, Fortune SM, Verma M, Jost M, Beura LK, James MJ, Lee SY, Mitchell CM, Clardy J, Kim KH, Gopinath S. Glick VJ, et al. Among authors: fortune sm. Cell Host Microbe. 2024 Oct 15:S1931-3128(24)00358-5. doi: 10.1016/j.chom.2024.09.014. Online ahead of print. Cell Host Microbe. 2024. PMID: 39423813
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection.
Bromley JD, Ganchua SKC, Nyquist SK, Maiello P, Chao M, Borish HJ, Rodgers M, Tomko J, Kracinovsky K, Mugahid D, Nguyen S, Wang QD, Rosenberg JM, Klein EC, Gideon HP, Floyd-O'Sullivan R, Berger B, Scanga CA, Lin PL, Fortune SM, Shalek AK, Flynn JL. Bromley JD, et al. Among authors: fortune sm. Immunity. 2024 Oct 8;57(10):2380-2398.e6. doi: 10.1016/j.immuni.2024.08.002. Epub 2024 Aug 29. Immunity. 2024. PMID: 39214090 Free PMC article.
135 results