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The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias.
Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L. Tsai MM, et al. Among authors: baumann mh. bioRxiv [Preprint]. 2023 Nov 15:2023.11.10.566672. doi: 10.1101/2023.11.10.566672. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2024 Feb 21;15(4):854-867. doi: 10.1021/acschemneuro.3c00750. PMID: 38014284 Free PMC article. Updated. Preprint.
A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor.
Yano H, Chitsazi R, Lucaj C, Tran P, Hoffman AF, Baumann MH, Lupica CR, Shi L. Yano H, et al. Among authors: baumann mh. bioRxiv [Preprint]. 2023 Jun 12:2023.06.10.544442. doi: 10.1101/2023.06.10.544442. bioRxiv. 2023. Update in: ACS Chem Neurosci. 2023 Nov 1;14(21):3928-3940. doi: 10.1021/acschemneuro.3c00530. PMID: 37398099 Free PMC article. Updated. Preprint.
311 results