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Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier.
Maram L, Michael JM, Politte H, Srirama VS, Hadji A, Habibi M, Kelly MO, Brookheart RT, Finck BN, Hegazy L, McCommis KS, Elgendy B. Maram L, et al. Among authors: elgendy b. Eur J Med Chem. 2025 Feb 5;283:117150. doi: 10.1016/j.ejmech.2024.117150. Epub 2024 Dec 11. Eur J Med Chem. 2025. PMID: 39708766 Free article.
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.
Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Billon C, et al. Among authors: elgendy b. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. ACS Chem Biol. 2023. PMID: 36988910 Free PMC article.
Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.
Murray MH, Valfort AC, Koelblen T, Ronin C, Ciesielski F, Chatterjee A, Veerakanellore GB, Elgendy B, Walker JK, Hegazy L, Burris TP. Murray MH, et al. Among authors: elgendy b. Nat Commun. 2022 Nov 21;13(1):7131. doi: 10.1038/s41467-022-34892-4. Nat Commun. 2022. PMID: 36414641 Free PMC article.
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.
Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA, Korach KS, Cain DW, Hollenberg AN, Webb P, Forrest D, Jetten AM, Edwards DP, Grimm SL, Hartig S, Lange CA, Richer JK, Sartorius CA, Tetel M, Billon C, Elgendy B, Hegazy L, Griffett K, Peinetti N, Burnstein KL, Hughes TS, Sitaula S, Stayrook KR, Culver A, Murray MH, Finck BN, Cidlowski JA. Burris TP, et al. Among authors: elgendy b. Pharmacol Rev. 2023 Nov;75(6):1233-1318. doi: 10.1124/pharmrev.121.000436. Epub 2023 Aug 16. Pharmacol Rev. 2023. PMID: 37586884 Free PMC article. Review.
A Synthetic ERR Agonist Alleviates Metabolic Syndrome.
Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. Billon C, et al. Among authors: elgendy b. J Pharmacol Exp Ther. 2024 Jan 17;388(2):232-240. doi: 10.1124/jpet.123.001733. J Pharmacol Exp Ther. 2024. PMID: 37739806
Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.
Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M. Wang XX, et al. Among authors: elgendy b. Am J Pathol. 2023 Dec;193(12):1969-1987. doi: 10.1016/j.ajpath.2023.07.008. Epub 2023 Sep 17. Am J Pathol. 2023. PMID: 37717940 Free PMC article.
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