Malik I - Search Results

1

Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.

Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, Kuttenlochner W, Liebhart E, Kulik A, Staudt ND, Malik I, Grond S, Sieber SA, Kaysser L, Groll M, Brötz-Oesterhelt H. Illigmann A, et al. Among authors: malik i. Angew Chem Int Ed Engl. 2024 Jan 15;63(3):e202314028. doi: 10.1002/anie.202314028. Epub 2023 Dec 12. Angew Chem Int Ed Engl. 2024. PMID: 38029352

2

Conformational control of the bacterial Clp protease by natural product antibiotics.

Malik IT, Brötz-Oesterhelt H. Malik IT, et al. Nat Prod Rep. 2017 Jul 6;34(7):815-831. doi: 10.1039/c6np00125d. Nat Prod Rep. 2017. PMID: 28375422 Review.

3

Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes.

Malik IT, Pereira R, Vielberg MT, Mayer C, Straetener J, Thomy D, Famulla K, Castro H, Sass P, Groll M, Brötz-Oesterhelt H. Malik IT, et al. Chembiochem. 2020 Jul 16;21(14):1997-2012. doi: 10.1002/cbic.201900787. Epub 2020 Apr 9. Chembiochem. 2020. PMID: 32181548 Free PMC article.

4

Generation of Lasso Peptide-Based ClpP Binders.

Malik IT, Hegemann JD, Brötz-Oesterhelt H. Malik IT, et al. Int J Mol Sci. 2021 Dec 31;23(1):465. doi: 10.3390/ijms23010465. Int J Mol Sci. 2021. PMID: 35008890 Free PMC article.

5

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

Gersch M, Famulla K, Dahmen M, Göbl C, Malik I, Richter K, Korotkov VS, Sass P, Rübsamen-Schaeff H, Madl T, Brötz-Oesterhelt H, Sieber SA. Gersch M, et al. Among authors: malik i. Nat Commun. 2015 Feb 19;6:6320. doi: 10.1038/ncomms7320. Nat Commun. 2015. PMID: 25695750 Free article.

6

Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes.

Dietrich A, Steffens U, Gajdiss M, Boschert AL, Dröge JK, Szekat C, Sass P, Malik IT, Bornikoel J, Reinke L, Maček B, Franz-Wachtel M, Nieselt K, Harbig T, Scherlach K, Brötz-Oesterhelt H, Hertweck C, Sahl HG, Bierbaum G. Dietrich A, et al. Microbiol Spectr. 2022 Oct 26;10(5):e0256722. doi: 10.1128/spectrum.02567-22. Epub 2022 Sep 29. Microbiol Spectr. 2022. PMID: 36173303 Free PMC article.

7

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.

Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H. Famulla K, et al. Among authors: malik i. Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1. Mol Microbiol. 2016. PMID: 26919556 Free PMC article.

8

The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci.

Pan S, Malik IT, Thomy D, Henrichfreise B, Sass P. Pan S, et al. Sci Rep. 2019 Oct 1;9(1):14129. doi: 10.1038/s41598-019-50505-5. Sci Rep. 2019. PMID: 31575885 Free PMC article.

9

Efficacy of echolaser smart interface-guided laser ablation in volume reduction of symptomatic benign thyroid nodules.

Malik I, Mitchell J, Thomas J. Malik I, et al. Front Endocrinol (Lausanne). 2024 Oct 9;15:1402522. doi: 10.3389/fendo.2024.1402522. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39444453 Free PMC article.

10

Coronary Revascularization Guided With Fractional Flow Reserve or Instantaneous Wave-Free Ratio: A 5-Year Follow-Up of the DEFINE FLAIR Randomized Clinical Trial.

Escaned J, Travieso A, Dehbi HM, Nijjer SS, Sen S, Petraco R, Patel M, Serruys PW, Davies J; DEFINE FLAIR Investigators. Escaned J, et al. JAMA Cardiol. 2024 Oct 16. doi: 10.1001/jamacardio.2024.3314. Online ahead of print. JAMA Cardiol. 2024. PMID: 39412778

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