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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Harrison DE, et al. Among authors: kirkland jl. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2. Geroscience. 2024. PMID: 38041783 Free PMC article.
A chronic wound model to investigate skin cellular senescence.
Wyles SP, Dashti P, Pirtskhalava T, Tekin B, Inman C, Gomez LS, Lagnado AB, Prata L, Jurk D, Passos JF, Tchkonia T, Kirkland JL. Wyles SP, et al. Among authors: kirkland jl. Aging (Albany NY). 2023 Apr 21;15(8):2852-2862. doi: 10.18632/aging.204667. Epub 2023 Apr 21. Aging (Albany NY). 2023. PMID: 37086260 Free PMC article.
In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S. Samakkarnthai P, et al. Among authors: kirkland jl. Aging (Albany NY). 2023 May 7;15(9):3331-3355. doi: 10.18632/aging.204701. Epub 2023 May 7. Aging (Albany NY). 2023. PMID: 37154858 Free PMC article.
Mapping cellular senescence networks in human diabetic foot ulcers.
Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP. Yu GT, et al. Among authors: kirkland jl. Geroscience. 2024 Feb;46(1):1071-1082. doi: 10.1007/s11357-023-00854-x. Epub 2023 Jun 29. Geroscience. 2024. PMID: 37380899 Free PMC article.
Past and Future Directions for Research on Cellular Senescence.
Zhu Y, Anastasiadis ZP, Espindola Netto JM, Evans T, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: kirkland jl. Cold Spring Harb Perspect Med. 2024 Feb 1;14(2):a041205. doi: 10.1101/cshperspect.a041205. Cold Spring Harb Perspect Med. 2024. PMID: 37734865 Review.
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
Wang B, Wang L, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Wang B, et al. Among authors: kirkland jl. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. doi: 10.1016/j.cmet.2024.07.006. Cell Metab. 2024. PMID: 39111286
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: kirkland jl. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases.
Suda M, Paul KH, Minamino T, Miller JD, Lerman A, Ellison-Hughes GM, Tchkonia T, Kirkland JL. Suda M, et al. Among authors: kirkland jl. Cells. 2023 May 2;12(9):1296. doi: 10.3390/cells12091296. Cells. 2023. PMID: 37174697 Free PMC article. Review.
370 results