Xiong XF - Search Results

1

Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma.

Fan G, Liu L, Ye J, Xiao W, Xiong XF. Fan G, et al. Among authors: xiong xf. Bioorg Chem. 2024 Feb;143:107005. doi: 10.1016/j.bioorg.2023.107005. Epub 2023 Nov 29. Bioorg Chem. 2024. PMID: 38043397

2

Design, Synthesis, and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma.

Ge Y, Shi S, Deng JJ, Chen XP, Song Z, Liu L, Lou L, Zhang X, Xiong XF. Ge Y, et al. Among authors: xiong xf. J Med Chem. 2021 Mar 25;64(6):3131-3152. doi: 10.1021/acs.jmedchem.0c01977. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715360

3

Targeting mutated GTPase KRAS in tumor therapies.

Fan G, Lou L, Song Z, Zhang X, Xiong XF. Fan G, et al. Among authors: xiong xf. Eur J Med Chem. 2021 Dec 15;226:113816. doi: 10.1016/j.ejmech.2021.113816. Epub 2021 Sep 4. Eur J Med Chem. 2021. PMID: 34520956 Review.

4

Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.

Song Z, Huang YY, Hou KQ, Liu L, Zhou F, Huang Y, Wan G, Luo HB, Xiong XF. Song Z, et al. Among authors: xiong xf. J Med Chem. 2022 Mar 10;65(5):4238-4254. doi: 10.1021/acs.jmedchem.1c02058. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188767

5

On-Resin Synthesis of Linear Aryl Thioether Containing Peptides and in-Solution Cyclization via Cysteine S_NAr Reaction.

Li J, Lai W, Pang A, Liu L, Ye L, Xiong XF. Li J, et al. Among authors: xiong xf. Org Lett. 2022 Mar 4;24(8):1673-1677. doi: 10.1021/acs.orglett.2c00234. Epub 2022 Feb 23. Org Lett. 2022. PMID: 35195423

6

Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.

Zhou F, Huang Y, Liu L, Song Z, Hou KQ, Yang Y, Luo HB, Huang YY, Xiong XF. Zhou F, et al. Among authors: xiong xf. Biochem Pharmacol. 2022 Aug;202:115123. doi: 10.1016/j.bcp.2022.115123. Epub 2022 Jun 8. Biochem Pharmacol. 2022. PMID: 35688178

7

Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.

Deng JJ, Liu L, Ge Y, Song Z, Huang J, Fan G, Xiong XF. Deng JJ, et al. Among authors: xiong xf. Eur J Med Chem. 2022 Sep 5;239:114520. doi: 10.1016/j.ejmech.2022.114520. Epub 2022 Jun 11. Eur J Med Chem. 2022. PMID: 35716516

8

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.

Ge Y, Deng JJ, Zhu J, Liu L, Ouyang S, Song Z, Zhang X, Xiong XF. Ge Y, et al. Among authors: xiong xf. Acta Pharm Sin B. 2022 Aug;12(8):3326-3340. doi: 10.1016/j.apsb.2022.04.016. Epub 2022 May 4. Acta Pharm Sin B. 2022. PMID: 35967274 Free PMC article.

9

Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.

Song Z, Lou L, Fan G, Liu L, Ge Y, Liu H, Chan ASC, Zhang X, Xiong XF. Song Z, et al. Among authors: xiong xf. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114907. doi: 10.1016/j.ejmech.2022.114907. Epub 2022 Nov 9. Eur J Med Chem. 2023. PMID: 36395648

10

Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Liu L, Song Z, Fan G, Lou L, Wang Y, Zhang X, Xiong XF. Liu L, et al. Among authors: xiong xf. Bioorg Med Chem. 2023 Oct 1;93:117457. doi: 10.1016/j.bmc.2023.117457. Epub 2023 Aug 25. Bioorg Med Chem. 2023. PMID: 37688996

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