Huang R - Search Results

1

A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.

Deng Y, Song X, Iyamu ID, Dong A, Min J, Huang R. Deng Y, et al. Among authors: huang r. Acta Pharm Sin B. 2023 Dec;13(12):4893-4905. doi: 10.1016/j.apsb.2023.07.022. Epub 2023 Jul 29. Acta Pharm Sin B. 2023. PMID: 38045046 Free PMC article.

2

Structural basis for substrate recognition by the human N-terminal methyltransferase 1.

Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min J. Dong C, et al. Among authors: huang r. Genes Dev. 2015 Nov 15;29(22):2343-8. doi: 10.1101/gad.270611.115. Epub 2015 Nov 5. Genes Dev. 2015. PMID: 26543161 Free PMC article.

3

An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.

Dong C, Dong G, Li L, Zhu L, Tempel W, Liu Y, Huang R, Min J. Dong C, et al. Among authors: huang r. Commun Biol. 2018 Nov 2;1:183. doi: 10.1038/s42003-018-0196-2. eCollection 2018. Commun Biol. 2018. PMID: 30417120 Free PMC article.

4

Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide N-Methyltransferase.

Chen D, Li L, Diaz K, Iyamu ID, Yadav R, Noinaj N, Huang R. Chen D, et al. Among authors: huang r. J Med Chem. 2019 Dec 12;62(23):10783-10797. doi: 10.1021/acs.jmedchem.9b01255. Epub 2019 Dec 3. J Med Chem. 2019. PMID: 31724854 Free PMC article.

5

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.

Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R. Chen D, et al. Among authors: huang r. J Med Chem. 2020 Aug 13;63(15):8419-8431. doi: 10.1021/acs.jmedchem.0c00770. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32605369 Free PMC article.

6

Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase.

Iyamu ID, Huang R. Iyamu ID, et al. Among authors: huang r. Anal Biochem. 2020 Sep 1;604:113833. doi: 10.1016/j.ab.2020.113833. Epub 2020 Jul 2. Anal Biochem. 2020. PMID: 32622979 Free PMC article.

7

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.

Mackie BD, Chen D, Dong G, Dong C, Parker H, Schaner Tooley CE, Noinaj N, Min J, Huang R. Mackie BD, et al. Among authors: huang r. J Med Chem. 2020 Sep 10;63(17):9512-9522. doi: 10.1021/acs.jmedchem.0c00689. Epub 2020 Aug 5. J Med Chem. 2020. PMID: 32689795 Free PMC article.

8

Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.

Chen D, Dong G, Deng Y, Noinaj N, Huang R. Chen D, et al. Among authors: huang r. ACS Med Chem Lett. 2021 Mar 1;12(3):485-493. doi: 10.1021/acsmedchemlett.1c00012. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738076 Free PMC article.

9

Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.

Deng Y, Deng S, Ho YH, Gardner SM, Huang Z, Marmorstein R, Huang R. Deng Y, et al. Among authors: huang r, huang z. J Med Chem. 2021 Jun 24;64(12):8263-8271. doi: 10.1021/acs.jmedchem.1c00141. Epub 2021 Jun 10. J Med Chem. 2021. PMID: 34110812 Free PMC article.

10

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes.

Iyamu ID, Al-Hamashi AA, Huang R. Iyamu ID, et al. Among authors: huang r. Biomolecules. 2021 Jun 8;11(6):854. doi: 10.3390/biom11060854. Biomolecules. 2021. PMID: 34201091 Free PMC article.

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