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Page 1
Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease.
Albani S, Costanzi E, Hoang GL, Kuzikov M, Frings M, Ansari N, Demitri N, Nguyen TT, Rizzi V, Schulz JB, Bolm C, Zaliani A, Carloni P, Storici P, Rossetti G. Albani S, et al. Among authors: costanzi e. J Chem Inf Model. 2024 Feb 12;64(3):892-904. doi: 10.1021/acs.jcim.3c01497. Epub 2023 Dec 5. J Chem Inf Model. 2024. PMID: 38051605 Free PMC article.
Identification and characterization of three novel mutations in the CASQ1 gene in four patients with tubular aggregate myopathy.
Barone V, Del Re V, Gamberucci A, Polverino V, Galli L, Rossi D, Costanzi E, Toniolo L, Berti G, Malandrini A, Ricci G, Siciliano G, Vattemi G, Tomelleri G, Pierantozzi E, Spinozzi S, Volpi N, Fulceri R, Battistutta R, Reggiani C, Sorrentino V. Barone V, et al. Among authors: costanzi e. Hum Mutat. 2017 Dec;38(12):1761-1773. doi: 10.1002/humu.23338. Epub 2017 Sep 26. Hum Mutat. 2017. PMID: 28895244
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.
Gossen J, Albani S, Hanke A, Joseph BP, Bergh C, Kuzikov M, Costanzi E, Manelfi C, Storici P, Gribbon P, Beccari AR, Talarico C, Spyrakis F, Lindahl E, Zaliani A, Carloni P, Wade RC, Musiani F, Kokh DB, Rossetti G. Gossen J, et al. Among authors: costanzi e. ACS Pharmacol Transl Sci. 2021 Mar 16;4(3):1079-1095. doi: 10.1021/acsptsci.0c00215. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 34136757 Free PMC article.
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen.
Kuzikov M, Costanzi E, Reinshagen J, Esposito F, Vangeel L, Wolf M, Ellinger B, Claussen C, Geisslinger G, Corona A, Iaconis D, Talarico C, Manelfi C, Cannalire R, Rossetti G, Gossen J, Albani S, Musiani F, Herzog K, Ye Y, Giabbai B, Demitri N, Jochmans D, Jonghe S, Rymenants J, Summa V, Tramontano E, Beccari AR, Leyssen P, Storici P, Neyts J, Gribbon P, Zaliani A. Kuzikov M, et al. Among authors: costanzi e. ACS Pharmacol Transl Sci. 2021 Mar 11;4(3):1096-1110. doi: 10.1021/acsptsci.0c00216. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 35287429 Free PMC article.
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination.
Stefanelli I, Corona A, Cerchia C, Cassese E, Improta S, Costanzi E, Pelliccia S, Morasso S, Esposito F, Paulis A, Scognamiglio S, Di Leva FS, Storici P, Brindisi M, Tramontano E, Cannalire R, Summa V. Stefanelli I, et al. Among authors: costanzi e. Eur J Med Chem. 2023 May 5;253:115311. doi: 10.1016/j.ejmech.2023.115311. Epub 2023 Mar 31. Eur J Med Chem. 2023. PMID: 37043904 Free PMC article.
Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity.
Iacobucci I, Cipollone I, Cozzolino F, Iaconis D, Talarico C, Coppola G, Morasso S, Costanzi E, Malune P, Storici P, Tramontano E, Esposito F, Monti M. Iacobucci I, et al. Among authors: costanzi e. Int J Biol Macromol. 2025 Jan 7:139590. doi: 10.1016/j.ijbiomac.2025.139590. Online ahead of print. Int J Biol Macromol. 2025. PMID: 39788258
Structure-Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR.
Carlino L, Christodoulou MS, Restelli V, Caporuscio F, Foschi F, Semrau MS, Costanzi E, Tinivella A, Pinzi L, Lo Presti L, Battistutta R, Storici P, Broggini M, Passarella D, Rastelli G. Carlino L, et al. Among authors: costanzi e. ChemMedChem. 2018 Dec 20;13(24):2627-2634. doi: 10.1002/cmdc.201800687. Epub 2018 Nov 20. ChemMedChem. 2018. PMID: 30457710 Free article.
A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling.
Bellanda M, Damulewicz M, Zambelli B, Costanzi E, Gregoris F, Mammi S, Tosatto SCE, Costa R, Minervini G, Mazzotta GM. Bellanda M, et al. Among authors: costanzi e. Protein Sci. 2024 Mar;33(3):e4914. doi: 10.1002/pro.4914. Protein Sci. 2024. PMID: 38358255
72 results