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846 results

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Page 1
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko DS, Moroz YS, Irwin JJ, Renslo AR, Taylor JC, Gestwicki JE, von Delft F, Ashworth A, Ahel I, Shoichet BK, Fraser JS. Gahbauer S, et al. Among authors: ashworth a. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2212931120. doi: 10.1073/pnas.2212931120. Epub 2023 Jan 4. Proc Natl Acad Sci U S A. 2023. PMID: 36598939 Free PMC article.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. Among authors: ashworth a. PLoS Pathog. 2023 Aug 31;19(8):e1011614. doi: 10.1371/journal.ppat.1011614. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37651466 Free PMC article.
Generation and Comparative Analysis of an Itga8-CreER T2 Mouse with Preferential Activity in Vascular Smooth Muscle Cells.
Warthi G, Faulkner JL, Doja J, Ghanam AR, Gao P, Yang AC, Slivano OJ, Barris CT, Kress TC, Zawieja SD, Griffin SH, Xie X, Ashworth A, Christie CK, Bryant WB, Kumar A, Davis MJ, Long X, Gan L, Belin de Chantemele EJ, Lyu Q, Miano JM. Warthi G, et al. Among authors: ashworth a. Nat Cardiovasc Res. 2022 Nov;1(11):1084-1100. doi: 10.1038/s44161-022-00162-1. Epub 2022 Nov 11. Nat Cardiovasc Res. 2022. PMID: 36424917 Free PMC article.
Author Correction: Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells.
Warthi G, Faulkner JL, Doja J, Ghanam AR, Gao P, Yang AC, Slivano OJ, Barris CT, Kress TC, Zawieja SD, Griffin SH, Xie X, Ashworth A, Christie CK, Bryant WB, Kumar A, Davis MJ, Long X, Gan L, Belin de Chantemèle EJ, Lyu QR, Miano JM. Warthi G, et al. Among authors: ashworth a. Nat Cardiovasc Res. 2023 Jul;2(7):702. doi: 10.1038/s44161-023-00301-2. Nat Cardiovasc Res. 2023. PMID: 39195929 No abstract available.
TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage.
Calses PC, Pham VC, Guarnaccia AD, Choi M, Verschueren E, Bakker ST, Pham TH, Hinkle T, Liu C, Chang MT, Kljavin N, Bakalarski C, Haley B, Zou J, Yan C, Song X, Lin X, Rowntree R, Ashworth A, Dey A, Lill JR. Calses PC, et al. Among authors: ashworth a. Mol Cell Proteomics. 2023 Feb;22(2):100496. doi: 10.1016/j.mcpro.2023.100496. Epub 2023 Jan 12. Mol Cell Proteomics. 2023. PMID: 36640924 Free PMC article.
Androgen receptor inhibition increases MHC Class I expression and improves immune response in prostate cancer.
Chesner LN, Polesso F, Graff JN, Hawley JE, Smith AK, Lundberg A, Das R, Shenoy T, Sjöström M, Zhao F, Hu YM, Linder S, Chen WS, Hawkins RM, Shrestha R, Zhu X, Foye A, Li H, Kim LM, Bhalla M, O'loughlin T, Kuzuoglu-Ozturk D, Hua JT, Badura ML, Wilkinson S, Trostel SY, Bergman AM, Ruggero D, Drake CG, Sowalsky AG, Fong L, Cooperberg MR, Zwart W, Guan X, Ashworth A, Xia Z, Quigley DA, Gilbert LA, Feng FY, Moran AE. Chesner LN, et al. Among authors: ashworth a. Cancer Discov. 2024 Dec 5. doi: 10.1158/2159-8290.CD-24-0559. Online ahead of print. Cancer Discov. 2024. PMID: 39652470
Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England.
Woods B, Kearns B, Schmitt L, Jankovic D, Rothery C, Harnan S, Hamilton J, Scope A, Ren S, Bojke L, Wilcox M, Hope W, Leonard C, Howard P, Jenkins D, Ashworth A, Bentley A, Sculpher M. Woods B, et al. Among authors: ashworth a. Appl Health Econ Health Policy. 2025 Jan;23(1):5-17. doi: 10.1007/s40258-024-00924-x. Epub 2024 Nov 30. Appl Health Econ Health Policy. 2025. PMID: 39616299 Free article.
Incidence of diabetes mellitus following hospitalisation for COVID-19 in the United Kingdom: A prospective observational study.
Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F, Yates T, Davies MJ, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Evans RA, Greening NJ, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Leavy OC, Lone NI, Marks M, McAuley HJC, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders R, Sereno M, Shikotra A, Singapuri A, Wain LV, Khunti K; PHOSP‐COVID Study Collaborative Group. Tyrer F, et al. Diabetes Obes Metab. 2025 Feb;27(2):767-776. doi: 10.1111/dom.16071. Epub 2024 Nov 20. Diabetes Obes Metab. 2025. PMID: 39563623 Free PMC article.
846 results