Shokat KM - Search Results

1

Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.

Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H. Malakoutikhah M, et al. Among authors: shokat km. Anal Chem. 2023 Dec 19;95(50):18344-18351. doi: 10.1021/acs.analchem.3c02844. Epub 2023 Dec 7. Anal Chem. 2023. PMID: 38060502 Free PMC article.

2

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.

Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. Guiley KZ, et al. Among authors: shokat km. Science. 2019 Dec 13;366(6471):eaaw2106. doi: 10.1126/science.aaw2106. Science. 2019. PMID: 31831640 Free PMC article.

3

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.

Zhang Z, Gao R, Hu Q, Peacock H, Peacock DM, Dai S, Shokat KM, Suga H. Zhang Z, et al. Among authors: shokat km. ACS Cent Sci. 2020 Oct 28;6(10):1753-1761. doi: 10.1021/acscentsci.0c00514. Epub 2020 Sep 23. ACS Cent Sci. 2020. PMID: 33145412 Free PMC article.

4

Drugging the Next Undruggable KRAS Allele-Gly12Asp.

Zheng Q, Peacock DM, Shokat KM. Zheng Q, et al. Among authors: shokat km. J Med Chem. 2022 Feb 24;65(4):3119-3122. doi: 10.1021/acs.jmedchem.2c00099. Epub 2022 Feb 15. J Med Chem. 2022. PMID: 35167298 Review.

5

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).

Zhang Z, Guiley KZ, Shokat KM. Zhang Z, et al. Among authors: shokat km. Nat Chem Biol. 2022 Nov;18(11):1177-1183. doi: 10.1038/s41589-022-01065-9. Epub 2022 Jul 21. Nat Chem Biol. 2022. PMID: 35864332 Free PMC article.

6

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.

Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM. Zhang Z, et al. Among authors: shokat km. J Am Chem Soc. 2022 Sep 7;144(35):15916-15921. doi: 10.1021/jacs.2c05377. Epub 2022 Aug 24. J Am Chem Soc. 2022. PMID: 36001446 Free PMC article.

7

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.

Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM. Dai SA, et al. Among authors: shokat km. Cell. 2022 Oct 13;185(21):3950-3965.e25. doi: 10.1016/j.cell.2022.09.019. Epub 2022 Sep 27. Cell. 2022. PMID: 36170854 Free PMC article.

8

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.

Guiley KZ, Shokat KM. Guiley KZ, et al. Among authors: shokat km. Cancer Discov. 2023 Jan 9;13(1):56-69. doi: 10.1158/2159-8290.CD-22-0381. Cancer Discov. 2023. PMID: 36197521 Free PMC article.

9

Evolutionarily divergent mTOR remodels translatome for tissue regeneration.

Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Öztürk D, Zhang Z, Ruggero D, Shokat KM, Barna M. Zhulyn O, et al. Among authors: shokat km, shokat l. Nature. 2023 Aug;620(7972):163-171. doi: 10.1038/s41586-023-06365-1. Epub 2023 Jul 26. Nature. 2023. PMID: 37495694 Free PMC article.

10

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.

Zheng Q, Zhang Z, Guiley KZ, Shokat KM. Zheng Q, et al. Among authors: shokat km. Nat Chem Biol. 2024 Sep;20(9):1114-1122. doi: 10.1038/s41589-024-01565-w. Epub 2024 Mar 5. Nat Chem Biol. 2024. PMID: 38443470 Free PMC article.

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