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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA. Fares MB, et al. Among authors: lashuel ha. Hum Mol Genet. 2014 Sep 1;23(17):4491-509. doi: 10.1093/hmg/ddu165. Epub 2014 Apr 11. Hum Mol Genet. 2014. PMID: 24728187 Free PMC article.
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.
Kumar ST, Donzelli S, Chiki A, Syed MMK, Lashuel HA. Kumar ST, et al. Among authors: lashuel ha. J Neurochem. 2020 Apr;153(1):103-119. doi: 10.1111/jnc.14955. Epub 2020 Feb 25. J Neurochem. 2020. PMID: 31925956 Free PMC article.
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA. Mahul-Mellier AL, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982. doi: 10.1073/pnas.1913904117. Epub 2020 Feb 19. Proc Natl Acad Sci U S A. 2020. PMID: 32075919 Free PMC article.
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
Cendrowska U, Silva PJ, Ait-Bouziad N, Müller M, Guven ZP, Vieweg S, Chiki A, Radamaker L, Kumar ST, Fändrich M, Tavanti F, Menziani MC, Alexander-Katz A, Stellacci F, Lashuel HA. Cendrowska U, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6866-6874. doi: 10.1073/pnas.1916176117. Epub 2020 Mar 11. Proc Natl Acad Sci U S A. 2020. PMID: 32161130 Free PMC article.
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology.
Kumar ST, Jagannath S, Francois C, Vanderstichele H, Stoops E, Lashuel HA. Kumar ST, et al. Among authors: lashuel ha. Neurobiol Dis. 2020 Dec;146:105086. doi: 10.1016/j.nbd.2020.105086. Epub 2020 Sep 22. Neurobiol Dis. 2020. PMID: 32971232 Free article.
209 results