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Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Aksu M, Kumar P, Güttler T, Taxer W, Gregor K, Mußil B, Rymarenko O, Stegmann KM, Dickmanns A, Gerber S, Reineking W, Schulz C, Henneck T, Mohamed A, Pohlmann G, Ramazanoglu M, Mese K, Groß U, Ben-Yedidia T, Ovadia O, Fischer DW, Kamensky M, Reichman A, Baumgärtner W, von Köckritz-Blickwede M, Dobbelstein M, Görlich D. Aksu M, et al. Among authors: dobbelstein m. Antiviral Res. 2024 Jan;221:105778. doi: 10.1016/j.antiviral.2023.105778. Epub 2023 Dec 7. Antiviral Res. 2024. PMID: 38065245 Free article.
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. Zibat A, et al. Among authors: dobbelstein m. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731621 Free PMC article.
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: dobbelstein m. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4'-fluorouridine.
Schrell L, Fuchs HL, Dickmanns A, Scheibner D, Olejnik J, Hume AJ, Reineking W, Störk T, Müller M, Graaf-Rau A, Diederich S, Finke S, Baumgärtner W, Mühlberger E, Balkema-Buschmann A, Dobbelstein M. Schrell L, et al. Among authors: dobbelstein m. Antiviral Res. 2024 Dec 3;233:106046. doi: 10.1016/j.antiviral.2024.106046. Online ahead of print. Antiviral Res. 2024. PMID: 39638153 Free article.
MDM4 exon skipping upon dysfunctional ribosome assembly.
Jansen J, Dobbelstein M. Jansen J, et al. Among authors: dobbelstein m. Trends Cell Biol. 2024 Nov 7:S0962-8924(24)00212-5. doi: 10.1016/j.tcb.2024.10.006. Online ahead of print. Trends Cell Biol. 2024. PMID: 39516053 Free article.
The interplay of TARG1 and PARG protects against genomic instability.
Groslambert J, Prokhorova E, Wondisford AR, Tromans-Coia C, Giansanti C, Jansen J, Timinszky G, Dobbelstein M, Ahel D, O'Sullivan RJ, Ahel I. Groslambert J, et al. Among authors: dobbelstein m. Cell Rep. 2023 Sep 26;42(9):113113. doi: 10.1016/j.celrep.2023.113113. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676774 Free PMC article.
Evaluation of N4-hydroxycytidine incorporation into nucleic acids of SARS-CoV-2-infected host cells by direct measurement with liquid chromatography-mass spectrometry.
Urbanowicz K, Opielka M, Stegmann KM, Dickmanns A, Dobbelstein M, Peters GJ, Smoleński RT. Urbanowicz K, et al. Among authors: dobbelstein m. Nucleosides Nucleotides Nucleic Acids. 2024;43(8):813-821. doi: 10.1080/15257770.2024.2346550. Epub 2024 May 13. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 38741480
132 results