Debnath A - Search Results

1

Miconazole-like Scaffold is a Promising Lead for Naegleria fowleri-Specific CYP51 Inhibitors.

Sharma V, Madia VN, Tudino V, Nguyen JV, Debnath A, Messore A, Ialongo D, Patacchini E, Palenca I, Basili Franzin S, Seguella L, Esposito G, Petrucci R, Di Matteo P, Bortolami M, Saccoliti F, Di Santo R, Scipione L, Costi R, Podust LM. Sharma V, et al. Among authors: debnath a. J Med Chem. 2023 Dec 28;66(24):17059-17073. doi: 10.1021/acs.jmedchem.3c01898. Epub 2023 Dec 12. J Med Chem. 2023. PMID: 38085955 Free PMC article.

2

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.

Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. Parsonage D, et al. Among authors: debnath a. J Struct Biol. 2016 May;194(2):180-90. doi: 10.1016/j.jsb.2016.02.015. Epub 2016 Feb 12. J Struct Biol. 2016. PMID: 26876147 Free PMC article.

3

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.

Jarrad AM, Debnath A, Miyamoto Y, Hansford KA, Pelingon R, Butler MS, Bains T, Karoli T, Blaskovich MA, Eckmann L, Cooper MA. Jarrad AM, et al. Among authors: debnath a. Eur J Med Chem. 2016 Sep 14;120:353-62. doi: 10.1016/j.ejmech.2016.04.064. Epub 2016 Apr 27. Eur J Med Chem. 2016. PMID: 27236016 Free PMC article.

4

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).

Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. Debnath A, et al. PLoS Negl Trop Dis. 2017 Dec 28;11(12):e0006104. doi: 10.1371/journal.pntd.0006104. eCollection 2017 Dec. PLoS Negl Trop Dis. 2017. PMID: 29284029 Free PMC article.

5

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.

Zhou W, Debnath A, Jennings G, Hahn HJ, Vanderloop BH, Chaudhuri M, Nes WD, Podust LM. Zhou W, et al. Among authors: debnath a. PLoS Pathog. 2018 Sep 13;14(9):e1007245. doi: 10.1371/journal.ppat.1007245. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30212566 Free PMC article.

6

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.

Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA. Jarrad AM, et al. Among authors: debnath a. J Med Chem. 2018 Dec 27;61(24):11349-11371. doi: 10.1021/acs.jmedchem.8b01578. Epub 2018 Dec 11. J Med Chem. 2018. PMID: 30468386 Free PMC article.

7

Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol Δ8-Δ7-Isomerase and Phenotypic Assays.

Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. Shi D, et al. Among authors: debnath a. ACS Infect Dis. 2019 Dec 13;5(12):2029-2038. doi: 10.1021/acsinfecdis.9b00227. Epub 2019 Oct 17. ACS Infect Dis. 2019. PMID: 31583882 Free PMC article.

8

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii.

Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. Shing B, et al. Among authors: debnath a. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e02223-19. doi: 10.1128/AAC.02223-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32094126 Free PMC article.

9

HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.

Hahn HJ, Abagyan R, Podust LM, Roy S, Ali IKM, Debnath A. Hahn HJ, et al. Among authors: debnath a. ACS Chem Neurosci. 2020 Oct 7;11(19):3089-3096. doi: 10.1021/acschemneuro.0c00428. Epub 2020 Sep 19. ACS Chem Neurosci. 2020. PMID: 32881478 Free PMC article.

10

Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole.

Sharma V, Shing B, Hernandez-Alvarez L, Debnath A, Podust LM. Sharma V, et al. Among authors: debnath a. Mol Pharmacol. 2020 Dec;98(6):770-780. doi: 10.1124/molpharm.120.000092. Epub 2020 Oct 2. Mol Pharmacol. 2020. PMID: 33008918 Free PMC article.

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