Adachi Y - Search Results

1

SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.

Lai X, Lui SKL, Lam HY, Adachi Y, Sim WJ, Vasilevski N, Armstrong NJ, Bridgeman SC, Main NM, Tan TZ, Tirnitz-Parker JEE, Thiery JP, Ebi H, Kumar AP, Eichhorn PJA. Lai X, et al. Among authors: adachi y. NPJ Precis Oncol. 2023 Dec 15;7(1):136. doi: 10.1038/s41698-023-00486-6. NPJ Precis Oncol. 2023. PMID: 38102334 Free PMC article.

2

Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer.

Kitai H, Ebi H, Tomida S, Floros KV, Kotani H, Adachi Y, Oizumi S, Nishimura M, Faber AC, Yano S. Kitai H, et al. Among authors: adachi y. Cancer Discov. 2016 Jul;6(7):754-69. doi: 10.1158/2159-8290.CD-15-1377. Epub 2016 May 6. Cancer Discov. 2016. PMID: 27154822 Free PMC article.

3

Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer.

Adachi Y, Watanabe K, Kita K, Kitai H, Kotani H, Sato Y, Inase N, Yano S, Ebi H. Adachi Y, et al. Carcinogenesis. 2017 Oct 26;38(11):1063-1072. doi: 10.1093/carcin/bgx091. Carcinogenesis. 2017. PMID: 28968756

4

Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers.

Kotani H, Adachi Y, Kitai H, Tomida S, Bando H, Faber AC, Yoshino T, Voon DC, Yano S, Ebi H. Kotani H, et al. Among authors: adachi y. Oncogene. 2018 Mar;37(13):1775-1787. doi: 10.1038/s41388-017-0035-9. Epub 2018 Jan 19. Oncogene. 2018. PMID: 29348459

5

Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C-Mutant Non-Small Cell Lung Cancer.

Adachi Y, Ito K, Hayashi Y, Kimura R, Tan TZ, Yamaguchi R, Ebi H. Adachi Y, et al. Clin Cancer Res. 2020 Nov 15;26(22):5962-5973. doi: 10.1158/1078-0432.CCR-20-2077. Epub 2020 Sep 8. Clin Cancer Res. 2020. PMID: 32900796

6

Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers.

Adachi Y, Kimura R, Hirade K, Ebi H. Adachi Y, et al. Cancers (Basel). 2021 Oct 11;13(20):5081. doi: 10.3390/cancers13205081. Cancers (Basel). 2021. PMID: 34680229 Free PMC article. Review.

7

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.

Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N. Su W, et al. Among authors: adachi y. Mol Cell. 2022 Jul 7;82(13):2443-2457.e7. doi: 10.1016/j.molcel.2022.04.034. Epub 2022 May 24. Mol Cell. 2022. PMID: 35613620 Free PMC article.

8

High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition.

Cai J, Jacob S, Kurupi R, Dalton KM, Coon C, Greninger P, Egan RK, Stein GT, Murchie E, McClanaghan J, Adachi Y, Hirade K, Dozmorov M, Glod J, Boikos SA, Ebi H, Hao H, Caponigro G, Benes CH, Faber AC. Cai J, et al. Among authors: adachi y. Cell Rep. 2022 Jul 26;40(4):111095. doi: 10.1016/j.celrep.2022.111095. Cell Rep. 2022. PMID: 35905710 Free PMC article.

9

Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.

Adachi Y, Kimura R, Hirade K, Yanase S, Nishioka Y, Kasuga N, Yamaguchi R, Ebi H. Adachi Y, et al. Nat Cancer. 2023 Jun;4(6):829-843. doi: 10.1038/s43018-023-00575-2. Epub 2023 Jun 5. Nat Cancer. 2023. PMID: 37277529

10

ARAF Amplification in Small-Cell Lung Cancer-Transformed Tumors Following Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors.

Kimura R, Adachi Y, Hirade K, Kisoda S, Yanase S, Shibata N, Ishii M, Fujiwara Y, Yamaguchi R, Fujita Y, Hosoda W, Ebi H. Kimura R, et al. Among authors: adachi y. Cancers (Basel). 2024 Oct 16;16(20):3501. doi: 10.3390/cancers16203501. Cancers (Basel). 2024. PMID: 39456595 Free PMC article.

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