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SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: keijer j. bioRxiv [Preprint]. 2023 Dec 8:2023.12.06.570371. doi: 10.1101/2023.12.06.570371. bioRxiv. 2023. PMID: 38105987 Free PMC article. Preprint.
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Yuan T, Kumar S, Skinner ME, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: keijer j. iScience. 2024 May 15;27(6):109991. doi: 10.1016/j.isci.2024.109991. eCollection 2024 Jun 21. iScience. 2024. PMID: 38846003 Free PMC article.
Mitochondrial Nicotinamide Nucleotide Transhydrogenase: Role in Energy Metabolism, Redox Homeostasis, and Cancer.
Gan Z, van der Stelt I, Li W, Hu L, Song J, Grefte S, van de Westerlo E, Zhang D, van Schothorst EM, Claahsen-van der Grinten HL, Teerds KJ, Adjobo-Hermans MJW, Keijer J, Koopman WJH. Gan Z, et al. Among authors: keijer j. Antioxid Redox Signal. 2024 Nov;41(13-15):927-956. doi: 10.1089/ars.2024.0694. Antioxid Redox Signal. 2024. PMID: 39585234 Review.
Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice.
Horakova O, Janovska P, Irodenko I, Buresova J, van der Stelt I, Stanic S, Haasova E, Shekhar N, Kobets T, Keijer J, Zouhar P, Rossmeisl M, Kopecky J, Bardova K. Horakova O, et al. Among authors: keijer j. Am J Physiol Endocrinol Metab. 2024 Dec 1;327(6):E729-E745. doi: 10.1152/ajpendo.00237.2024. Epub 2024 Oct 23. Am J Physiol Endocrinol Metab. 2024. PMID: 39441238
Ndufs4 knockout mice with isolated complex I deficiency engage a futile adaptive brain response.
van de Wal MAE, Doornbos C, Bibbe JM, Homberg JR, van Karnebeek C, Huynen MA, Keijer J, van Schothorst EM, 't Hoen PAC, Janssen MCH, Adjobo-Hermans MJW, Wieckowski MR, Koopman WJH. van de Wal MAE, et al. Among authors: keijer j. Biochim Biophys Acta Proteins Proteom. 2025 Jan 1;1873(1):141055. doi: 10.1016/j.bbapap.2024.141055. Epub 2024 Oct 11. Biochim Biophys Acta Proteins Proteom. 2025. PMID: 39395749 Free article.
TLCD4 as Potential Transcriptomic Biomarker of Cold Exposure.
Reynés B, García-Ruiz E, van Schothorst EM, Keijer J, Oliver P, Palou A. Reynés B, et al. Among authors: keijer j. Biomolecules. 2024 Aug 1;14(8):935. doi: 10.3390/biom14080935. Biomolecules. 2024. PMID: 39199323 Free PMC article.
Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA.
van Soest DMK, Polderman PE, den Toom WTF, Keijer JP, van Roosmalen MJ, Leyten TMF, Lehmann J, Zwakenberg S, De Henau S, van Boxtel R, Burgering BMT, Dansen TB. van Soest DMK, et al. Among authors: keijer jp. Nat Commun. 2024 Mar 28;15(1):2725. doi: 10.1038/s41467-024-47008-x. Nat Commun. 2024. PMID: 38548751 Free PMC article.
265 results