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SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology.
Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: stuckey ja. bioRxiv [Preprint]. 2023 Dec 8:2023.12.06.570371. doi: 10.1101/2023.12.06.570371. bioRxiv. 2023. PMID: 38105987 Free PMC article. Preprint.
Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Yuan T, Kumar S, Skinner ME, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, Alfadhel M, Spelbrink JN, Rodenburg R, de Boer VCJ, Lombard DB. Yuan T, et al. Among authors: stuckey ja. iScience. 2024 May 15;27(6):109991. doi: 10.1016/j.isci.2024.109991. eCollection 2024 Jun 21. iScience. 2024. PMID: 38846003 Free PMC article.
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang CY, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. Xu R, et al. Among authors: stuckey ja. J Med Chem. 2024 Nov 28;67(22):20495-20513. doi: 10.1021/acs.jmedchem.4c01946. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39509603
Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader.
Kaneshige A, Yang Y, Bai L, Wang M, Xu R, Mallik L, Chinnaswamy K, Metwally H, Wang Y, McEachern D, Tošović J, Yang CY, Kirchhoff PD, Meagher JL, Stuckey JA, Wang S. Kaneshige A, et al. Among authors: stuckey ja. J Med Chem. 2024 Sep 23. doi: 10.1021/acs.jmedchem.4c01009. Online ahead of print. J Med Chem. 2024. PMID: 39311434
Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells.
Yuan X, Sabzvar MK, Patil AD, Chinnaswamy K, Howie KL, Andhavaram R, Wang B, Siegler MA, Dumaz A, Stuckey JA, Corey SJ, Maciejewski JP, Visconte V, Yang CY. Yuan X, et al. Among authors: stuckey ja. Res Sq [Preprint]. 2024 Jun 3:rs.3.rs-4477663. doi: 10.21203/rs.3.rs-4477663/v1. Res Sq. 2024. PMID: 38883705 Free PMC article. Preprint.
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.
Yuan X, Jiang H, Fu D, Rech JC, Robida A, Rajanayake K, Yuan H, He M, Wen B, Sun D, Liu C, Chinnaswamy K, Stuckey JA, Paczesny S, Yang CY. Yuan X, et al. Among authors: stuckey ja. ACS Pharmacol Transl Sci. 2023 Aug 16;6(9):1275-1287. doi: 10.1021/acsptsci.3c00122. eCollection 2023 Sep 8. ACS Pharmacol Transl Sci. 2023. PMID: 37705593 Free PMC article.
118 results