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Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.
Bahnassawy L, Nicolaisen N, Untucht C, Mielich-Süss B, Reinhardt L, Ried JS, Morawe MP, Geist D, Finck A, Käfer E, Korffmann J, Townsend M, Ravikumar B, Lakics V, Cik M, Reinhardt P. Bahnassawy L, et al. Among authors: cik m. SLAS Discov. 2024 Mar;29(2):100137. doi: 10.1016/j.slasd.2023.12.009. Epub 2023 Dec 19. SLAS Discov. 2024. PMID: 38128829 Free article.
Tau in the brain interstitial fluid is fragmented and seeding-competent.
Barini E, Plotzky G, Mordashova Y, Hoppe J, Rodriguez-Correa E, Julier S, LePrieult F, Mairhofer I, Mezler M, Biesinger S, Cik M, Meinhardt MW, Ercan-Herbst E, Ehrnhoefer DE, Striebinger A, Bodie K, Klein C, Gasparini L, Schlegel K. Barini E, et al. Among authors: cik m. Neurobiol Aging. 2022 Jan;109:64-77. doi: 10.1016/j.neurobiolaging.2021.09.013. Epub 2021 Sep 17. Neurobiol Aging. 2022. PMID: 34655982 Free article.
Sustained synchronized neuronal network activity in a human astrocyte co-culture system.
Kuijlaars J, Oyelami T, Diels A, Rohrbacher J, Versweyveld S, Meneghello G, Tuefferd M, Verstraelen P, Detrez JR, Verschuuren M, De Vos WH, Meert T, Peeters PJ, Cik M, Nuydens R, Brône B, Verheyen A. Kuijlaars J, et al. Among authors: cik m. Sci Rep. 2016 Nov 7;6:36529. doi: 10.1038/srep36529. Sci Rep. 2016. PMID: 27819315 Free PMC article.
Using Human iPSC-Derived Neurons to Model TAU Aggregation.
Verheyen A, Diels A, Dijkmans J, Oyelami T, Meneghello G, Mertens L, Versweyveld S, Borgers M, Buist A, Peeters P, Cik M. Verheyen A, et al. Among authors: cik m. PLoS One. 2015 Dec 31;10(12):e0146127. doi: 10.1371/journal.pone.0146127. eCollection 2015. PLoS One. 2015. PMID: 26720731 Free PMC article.
34 results