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Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
Bauman AA, Sarathy JP, Kaya F, Massoudi LM, Scherman MS, Hastings C, Liu J, Xie M, Brooks EJ, Ramey ME, Jones IL, Benedict ND, Maclaughlin MR, Miller-Dawson JA, Waidyarachchi SL, Butler MM, Bowlin TL, Zimmerman MD, Lenaerts AJ, Meibohm B, Gonzalez-Juarrero M, Lyons MA, Dartois V, Lee RE, Robertson GT. Bauman AA, et al. Among authors: lenaerts aj. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0071624. doi: 10.1128/aac.00716-24. Epub 2024 Sep 30. Antimicrob Agents Chemother. 2024. PMID: 39345140 Free PMC article.
Enhancing the therapeutic window for Spectinamide anti-tuberculosis Agents: Synthesis, Evaluation, and activation of phosphate prodrug 3408.
Liu J, Lukka PB, Ektnitphong VA, Parmar KR, Wagh S, Lu Y, Lee RB, Scherbakov D, Wang H, Zimmerman MD, Meibohm B, Robertson GT, Dartois V, Böttger EC, Lenaerts AJ, Lee RE. Liu J, et al. Among authors: lenaerts aj. Bioorg Med Chem Lett. 2024 Nov 1;112:129934. doi: 10.1016/j.bmcl.2024.129934. Epub 2024 Aug 28. Bioorg Med Chem Lett. 2024. PMID: 39214506 Free article.
Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.
Bauman AA, Sarathy JP, Kaya F, Massoudi LM, Scherman MS, Hastings C, Liu J, Xie M, Brooks EJ, Ramey ME, Jones IL, Benedict ND, Maclaughlin MR, Miller-Dawson JA, Waidyarachchi SL, Butler MM, Bowlin TL, Zimmerman MD, Lenaerts AJ, Meibohm B, Gonzalez-Juarrero M, Lyons MA, Dartois V, Lee RE, Robertson GT. Bauman AA, et al. Among authors: lenaerts aj. bioRxiv [Preprint]. 2024 May 13:2024.05.13.593953. doi: 10.1101/2024.05.13.593953. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0071624. doi: 10.1128/aac.00716-24 PMID: 38798577 Free PMC article. Updated. Preprint.
Reduction of large vessel traffic improves water quality and alters fish habitat-use throughout a large river.
Spear MJ, Harris BS, Bookout TA, Ickes BS, Jankowski KJ, Solomon LE, Maxson KA, Whitten Harris AL, Mathis AT, Schaick SJ, Williams JA, DeBoer JA, Lenaerts AW, Hine EC, Chick JH, Lamer JT. Spear MJ, et al. Among authors: lenaerts aw. Sci Total Environ. 2024 Oct 10;946:172705. doi: 10.1016/j.scitotenv.2024.172705. Epub 2024 Apr 24. Sci Total Environ. 2024. PMID: 38670381 Free article.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
Boshoff HIM, Young K, Ahn YM, Yadav VD, Crowley BM, Yang L, Su J, Oh S, Arora K, Andrews J, Manikkam M, Sutphin M, Smith AJ, Weiner DM, Piazza MK, Fleegle JD, Gomez F, Dayao EK, Prideaux B, Zimmerman M, Kaya F, Sarathy J, Tan VY, Via LE, Tschirret-Guth R, Lenaerts AJ, Robertson GT, Dartois V, Olsen DB, Barry CE 3rd. Boshoff HIM, et al. Among authors: lenaerts aj. ACS Infect Dis. 2024 May 10;10(5):1679-1695. doi: 10.1021/acsinfecdis.4c00025. Epub 2024 Apr 6. ACS Infect Dis. 2024. PMID: 38581700
Self-Management Analysis in Chronic Conditions (SMACC) checklist: an international consensus-based tool to develop, compare and evaluate self-management support programmes.
Moreels T, Cruyt E, De Baets S, Andries L, Arts-Tielemans M, Rodriguez-Bailon M, Bergström A, Boete K, Bormans I, Costa U, Declercq H, Dekelver S, Dekyvere V, Delooz E, Engels C, Helderweirt S, Jarrey M, Lenaerts A, Leyman A, Lim KH, Meynen L, Satink T, Schoenmakers F, Senn D, Slembrouck L, Van Meensel E, Vangenechten D, Van Paepeghem B, De Vriendt P, Van de Velde D. Moreels T, et al. Among authors: lenaerts a. BMJ Open. 2023 Dec 20;13(12):e075676. doi: 10.1136/bmjopen-2023-075676. BMJ Open. 2023. PMID: 38128945 Free PMC article.
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model.
Ramey ME, Kaya F, Bauman AA, Massoudi LM, Sarathy JP, Zimmerman MD, Scott DWL, Job AM, Miller-Dawson JA, Podell BK, Lyons MA, Dartois V, Lenaerts AJ, Robertson GT. Ramey ME, et al. Among authors: lenaerts aj. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0059723. doi: 10.1128/aac.00597-23. Epub 2023 Oct 4. Antimicrob Agents Chemother. 2023. PMID: 37791784 Free PMC article.
Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency.
Papandreou A, Singh N, Gianfrancesco L, Budinger D, Barwick K, Agrotis A, Luft C, Shao Y, Lenaerts AS, Gregory A, Jeong SY, Hogarth P, Hayflick S, Barral S, Kriston-Vizi J, Gissen P, Kurian MA, Ketteler R. Papandreou A, et al. Among authors: lenaerts as. bioRxiv [Preprint]. 2024 Jun 17:2023.09.13.556416. doi: 10.1101/2023.09.13.556416. bioRxiv. 2024. PMID: 37745522 Free PMC article. Preprint.
159 results