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Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Heppner DE, Wittlinger F, Beyett TS, Shaurova T, Urul DA, Buckley B, Pham CD, Schaeffner IK, Yang B, Ogboo BC, May EW, Schaefer EM, Eck MJ, Laufer SA, Hershberger PA. Heppner DE, et al. Among authors: may ew. ACS Med Chem Lett. 2022 Nov 10;13(12):1856-1863. doi: 10.1021/acsmedchemlett.2c00213. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518696 Free PMC article.
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Heppner D, Wittlinger F, Ogboo B, Shevchenko E, Damghani T, Pham C, Schaeffner I, Oligny B, Chitnis S, Beyett T, Rasch A, Buckley B, Urul D, Shaurova T, May E, Schaefer E, Eck M, Hershberger P, Poso A, Laufer S. Heppner D, et al. Res Sq [Preprint]. 2023 Sep 13:rs.3.rs-3286949. doi: 10.21203/rs.3.rs-3286949/v1. Res Sq. 2023. Update in: Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3 PMID: 37790373 Free PMC article. Updated. Preprint.
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE. Wittlinger F, et al. Among authors: may ew. Commun Chem. 2024 Feb 20;7(1):38. doi: 10.1038/s42004-024-01108-3. Commun Chem. 2024. PMID: 38378740 Free PMC article.
Demystifying Functional Parameters for Irreversible Enzyme Inhibitors.
Heppner DE, Ogboo BC, Urul DA, May EW, Schaefer EM, Murkin AS, Gehringer M. Heppner DE, et al. Among authors: may ew. J Med Chem. 2024 Sep 12;67(17):14693-14696. doi: 10.1021/acs.jmedchem.4c01721. Epub 2024 Aug 8. J Med Chem. 2024. PMID: 39115869 No abstract available.
Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.
Wanner J, Romashko D, Werner DS, May EW, Peng Y, Schulz R, Foreman KW, Russo S, Arnold LD, Pingle M, Bergstrom DE, Barany F, Thomson S. Wanner J, et al. Among authors: may ew. PLoS One. 2015 Apr 15;10(4):e0121793. doi: 10.1371/journal.pone.0121793. eCollection 2015. PLoS One. 2015. PMID: 25875098 Free PMC article.
19 results