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Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine.
Cajander S, Kox M, Scicluna BP, Weigand MA, Mora RA, Flohé SB, Martin-Loeches I, Lachmann G, Girardis M, Garcia-Salido A, Brunkhorst FM, Bauer M, Torres A, Cossarizza A, Monneret G, Cavaillon JM, Shankar-Hari M, Giamarellos-Bourboulis EJ, Winkler MS, Skirecki T, Osuchowski M, Rubio I, Bermejo-Martin JF, Schefold JC, Venet F. Cajander S, et al. Among authors: scicluna bp. Lancet Respir Med. 2024 Apr;12(4):305-322. doi: 10.1016/S2213-2600(23)00330-2. Epub 2023 Dec 21. Lancet Respir Med. 2024. PMID: 38142698 Free article. Review.
Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.
Baillie JK, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, Hacohen N, Khatri P, Langley R, Ma'ayan A, Marshall J, Maslove D, Prescott HC, Rowan K, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Joost Wiersinga W, Singer M, Randolph AG. Baillie JK, et al. Among authors: scicluna bp. Intensive Care Med. 2024 Dec;50(12):2031-2042. doi: 10.1007/s00134-024-07665-4. Epub 2024 Oct 21. Intensive Care Med. 2024. PMID: 39432104 Free PMC article. Review.
Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.
van Amstel RBE, Kennedy JN, Scicluna BP, Bos LDJ, Peters-Sengers H, Butler JM, Cano-Gamez E, Knight JC, Vlaar APJ, Cremer OL, Angus DC, van der Poll T, Seymour CW, van Vught LA; MARS Consortium. van Amstel RBE, et al. Among authors: scicluna bp. Intensive Care Med. 2023 Nov;49(11):1360-1369. doi: 10.1007/s00134-023-07239-w. Epub 2023 Oct 18. Intensive Care Med. 2023. PMID: 37851064 Free PMC article.
Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis.
van Vught LA, Uhel F, Ding C, Van't Veer C, Scicluna BP, Peters-Sengers H, Klein Klouwenberg PMC, Nürnberg P, Cremer OL, Schultz MJ, van der Poll T; MARS consortium. van Vught LA, et al. Among authors: scicluna bp. J Thromb Haemost. 2021 Apr;19(4):1049-1063. doi: 10.1111/jth.15246. Epub 2021 Feb 17. J Thromb Haemost. 2021. PMID: 33492719 Free PMC article.
Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications.
Vrijmoeth HD, Ursinus J, Botey-Bataller J, Kuijpers Y, Chu X, van de Schoor FR, Scicluna BP, Xu CJ, Netea MG, Kullberg BJ, van den Wijngaard CC, Li Y, Hovius JW, Joosten LAB. Vrijmoeth HD, et al. Among authors: scicluna bp. BMC Infect Dis. 2024 Mar 21;24(1):337. doi: 10.1186/s12879-024-09217-z. BMC Infect Dis. 2024. PMID: 38515037 Free PMC article.
Isolating high-quality RNA for RNA-Seq from 10-year-old blood samples.
Portelli C, Seria E, Attard R, Barzine M, Esquinas-Roman EM, Borg Carbott F, Cassar K, Vella M, Scicluna BP, Ebejer JP, Farrugia R, Bezzina Wettinger S. Portelli C, et al. Among authors: scicluna bp. Sci Rep. 2024 Dec 28;14(1):30716. doi: 10.1038/s41598-024-80287-4. Sci Rep. 2024. PMID: 39730418 Free PMC article.
International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium.
Moore AR, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali MV, Levitt JE, van der Poll T, Scicluna BP, Giamarellos-Bourboulis EJ, Kotsaki A, Martin-Loeches I, Garduno A, Rothman RE, Sevransky J, Wright DW, Atreya MR, Moldawer LL, Efron PA, Marcela K, Karvunidis T, Giannini HM, Meyer NJ, Sweeney TE, Rogers AJ, Khatri P. Moore AR, et al. Among authors: scicluna bp. bioRxiv [Preprint]. 2024 Nov 15:2024.11.12.623298. doi: 10.1101/2024.11.12.623298. bioRxiv. 2024. PMID: 39605502 Free PMC article. Preprint.
Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.
Balk R, Esper AM, Martin GS, Miller RR 3rd, Lopansri BK, Burke JP, Levy M, Rothman RE, D'Alessio FR, Sidhaye VK, Aggarwal NR, Greenberg JA, Yoder M, Patel G, Gilbert E, Parada JP, Afshar M, Kempker JA, van der Poll T, Schultz MJ, Scicluna BP, Klein Klouwenberg PMC, Liebler J, Blodget E, Kumar S, Mei XW, Navalkar K, Yager TD, Sampson D, Kirk JT, Cermelli S, Davis RF, Brandon RB. Balk R, et al. Among authors: scicluna bp. J Clin Med. 2024 Oct 10;13(20):6044. doi: 10.3390/jcm13206044. J Clin Med. 2024. PMID: 39457994 Free PMC article.
Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia.
Reijnders TDY, Laterre PF, François B, Sánchez García M, van Engelen TSR, Sie D, Scicluna BP, Ostanin DV, Galinsky KJ, Butler JM, Lombardo E, van der Poll T; SEPCELL study group. Reijnders TDY, et al. Among authors: scicluna bp. Thorax. 2024 Oct 16;79(11):1086-1090. doi: 10.1136/thorax-2024-222026. Thorax. 2024. PMID: 39322407 Free PMC article. Clinical Trial.
137 results